Results 91 to 100 of about 8,532,574 (316)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Grounding nonexistence [PDF]

open access: yes, 2020
Contingent negative existentials give rise to a notorious paradox. I formulate a version in terms of metaphysical grounding: nonexistence can't be fundamental, but nothing can ground it.
Muñoz, Daniel
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Coding of geodesics on some modular surfaces and applications to odd and even continued fractions

open access: yes, 2018
The connection between geodesics on the modular surface $\operatorname{PSL}(2,{\mathbb Z})\backslash {\mathbb H}$ and regular continued fractions, established by Series, is extended to a connection between geodesics on $\Gamma\backslash {\mathbb H}$ and ...
Boca, Florin P., Merriman, Claire
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Direito Fundamental ao Envelhecimento Inclusivo / Fundamental right to inclusive aging

open access: yesRevista Direito e Práxis, 2011
Resumo Este trabalho aborda a relação dos idosos – enquanto categoria – no atual Estado Democrático de Direito, no que tange à promoção de programas e políticas sociais, num cenário de envelhecimento da população e diminuição de contribuintes aos fundos ...
Viviane Filgueiras Rojas   +1 more
doaj  

Good Administration as a Fundamental Right

open access: yes, 2013
The EU Charter of Fundamental Rights lists good administration as a fundamental right. The scope of this right, as defined in Article 41 of the EU Charter, is limited to situations in which persons are dealing with the institutions and bodies of the ...
Margrét Vala Kristjánsdóttir
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

The Dual Manifestation of the Right to Health in Colombia and Its Challenges Arising from Post-Pandemic Crises

open access: yesVia Inveniendi Et Iudicandi
The pandemic, declared in Colombia since March 2020, required a significant institutional and social effort to mitigate the effects of what was then an unknown disease.
César Alberto Correa-Martínez   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy