Results 91 to 100 of about 8,532,574 (316)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Contingent negative existentials give rise to a notorious paradox. I formulate a version in terms of metaphysical grounding: nonexistence can't be fundamental, but nothing can ground it.
Muñoz, Daniel
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Supreme Court of India judgement on abortion as a fundamental right: breaking new ground. [PDF]
Jain D.
europepmc +1 more source
Coding of geodesics on some modular surfaces and applications to odd and even continued fractions
The connection between geodesics on the modular surface $\operatorname{PSL}(2,{\mathbb Z})\backslash {\mathbb H}$ and regular continued fractions, established by Series, is extended to a connection between geodesics on $\Gamma\backslash {\mathbb H}$ and ...
Boca, Florin P., Merriman, Claire
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Direito Fundamental ao Envelhecimento Inclusivo / Fundamental right to inclusive aging
Resumo Este trabalho aborda a relação dos idosos – enquanto categoria – no atual Estado Democrático de Direito, no que tange à promoção de programas e políticas sociais, num cenário de envelhecimento da população e diminuição de contribuintes aos fundos ...
Viviane Filgueiras Rojas +1 more
doaj
Good Administration as a Fundamental Right
The EU Charter of Fundamental Rights lists good administration as a fundamental right. The scope of this right, as defined in Article 41 of the EU Charter, is limited to situations in which persons are dealing with the institutions and bodies of the ...
Margrét Vala Kristjánsdóttir
semanticscholar +1 more source
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
The pandemic, declared in Colombia since March 2020, required a significant institutional and social effort to mitigate the effects of what was then an unknown disease.
César Alberto Correa-Martínez +4 more
doaj +1 more source

