Results 141 to 150 of about 6,380,160 (306)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Stable pair invariants of surfaces and Seiberg-Witten invariants [PDF]
, 2016 Kool, M. +2 more
core +3 more sources
Classical and relative realizability [PDF]
, 2016 We show that every abstract Krivine structure in the sense of Streicher can be obtained, up to equivalence of the resulting tripos, from a filtered opca (A,A') and a subobject of 1 in the relative realizability topos RT(A',A); the topos is always a ...
Zou, Tingxiang +3 more
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The method of the fundamental solutions and its modifications for electromagnetic field problems
Computer Assisted Methods in Engineering and Science, 2017 The paper presents the method of fundamental solutions (MFS) for solving electromagnetic problems. We compare the MFS with the method of boundary integral equations in solution of potential problems.
C. S. Chen, S. Y. Reutskiy, V. Y. Rozov
doaj
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Connecting cycles for concentric circles [PDF]
, 2019 We study perimeters of connecting cycles for concentric circles. More precisely, we are interested in characterization of those connecting cycles which are critical points of perimeter considered as a function on the product of given circles ...
Khimshiashvili, Giorgi +3 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The myth of Leibniz’s proof of the fundamental theorem of calculus [PDF]
, 2015 Fundamental mathematics +2 more
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