FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Reduction of Np(v) to Np(iv) using oxalic acid: rethinking decades of nuclear processing conventions. [PDF]
RSC AdvGilson SE, Parker CJ, Lawson KM.
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
THE INTERNET BETWEEN PROMOTION AND INFRINGEMENT OF THE FUNDAMENTAL RIGHTS FREEDOMS vs. CYBERCRIMES [PDF]
The Internet has become a mean by which individuals can exercise their right to freedom of opinion and expression, as well as the freedom of association, which, both play a crucial role in supporting democracy and guaranteeing human rights.
Silvia-Maria Tăbușcă (Martiș)
core
When Mechanics Rewrites Chemistry: Divergent Pathways of Hardening and Softening in High Strength Al-Alloys. [PDF]
Adv Sci (Weinh)Zhao H +9 more
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
A Robust Equivalent Circuit Model for DNA-Mediated Electrochemistry. [PDF]
ChempluschemSeifi MO +4 more
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Deconvolution and Correction of the Inner Filter Effect in a Tri-Enzymatic Fluorescent Cascade for Ultra-Extended Cholesterol Quantification. [PDF]
LuminescenceYadav SK.
europepmc +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source