Results 111 to 120 of about 1,298,480 (281)
Stefan Czarnecki (born in 1925) graduated from Gdańsk Technical University in 1949 as an electronic engineer with specialization in acoustics. After several years of work at the Central Laboratory of the Polish Radio and at Warsaw Technical University ...
Editorial Committe and Board
doaj
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The synthesis of various heterocyclic base modifications of nucleic acids has been thoroughly investigated; however, much less is known about their catabolism.
Jaunius Urbonavičius +4 more
doaj +1 more source
The professions of science in America: their ambivalent history [PDF]
Science started to become professionalized in the United States during the Jackson~an period. A principal aim of professionalization was to secure the goals and standards of research from interference by laymen by the institutionalization of scientific
Kevles, Daniel J.
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Special issue: Innovations in farming systems approaches: Introduction [PDF]
absen
Bellon, S. +10 more
core +3 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
In this paper the purpose and manner of conducting the process of asymptotic homogenization of a type 1-3 composite structure are presented. The formulation of the homogenization process is reduced to numerical static analysis of an elementary symmetry ...
K. KYCIA, A. NOWICKI, O. GAJL, T.D. HIEN
doaj
Reductionism and the Universal Calculus [PDF]
In the seminal essay, "On the unreasonable effectiveness of mathematics in the physical sciences," physicist Eugene Wigner poses a fundamental philosophical question concerning the relationship between a physical system and our capacity to model its ...
Sarma, Gopal P.
core +1 more source
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source

