Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
AGRICULTURAL ECONOMICS RESEARCH AND THE EXPERIMENT STATION SYSTEM
This paper discusses the role of agricultural economics research within the land-grant university system. Fundamental differences between research in the biological sciences and the social sciences are delineated.
Debertin, David L., Bradford, Garnett L.
core
Material capacity of the fundamental science institutions: analysis of the research infrastructure condition and programs of the material and technical resources support of the basic researches sector [PDF]
NAUCHNOE PRIBOROSTROENIE, 2018 openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Generation and detection of incoherent hypersonic vibrations using superconducting tunnel junctions
Archives of Acoustics, 2016 The investigations of superconducting tunnel junctions as phonon generators and detectors are reported. Theoretical predictions and the published results of the experimental research on such devices are briefly reviewed.
Mikołaj ALEKSIEJUK +2 more
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Life sciences recruitment objectives
, 1992 The goals of the Life Sciences Division of the Office of Space Sciences and Application are to ensure the health, well being and productivity of humans in space and to acquire fundamental scientific knowledge in space life sciences.
Keefe, J. Richard
core
Protection of technical installations intended for use in Ex areas against explosions
This paper analyzes the fundamental methods and principles for protecting technical installations used in explosive atmospheres (Ex zones), in order to prevent catastrophic events.
Sorin Mihai Radu +3 more
core +1 more source
Rheological properties of epoxy resins in an shear ultrasonic field
Archives of Acoustics, 2015 Ultrasonic shear measurements were perfomed on epoxy resins: araldit F and epidian 5 in a temperature range from — 30 to 80°C and a frequency range from 10 to 800 MHz.
Ryszard PŁOWIEC
doaj