Results 61 to 70 of about 10,132 (240)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Role of fundamental sciences in evolution of coastal sciences

open access: yes, 2008
Современное береговедение сформировалось под влиянием всех фундаментальных наук (физики, математики, химии, биологии). Широкое применение береговедения в экономике обусловило его тесную связь с техническими науками и хозяйственной практикойСучасне ...
Стоян, Олександр Олександрович   +2 more
core  

Hydro-dynamically modified seeding for micro-PIV

open access: yesArchives of Mechanics, 2011
This paper presents numerical and experimental analysis of the hydrodynamic flow focusing in a rectangular microchannel. Aim of the study is to improve performance of the Particle Image Velocimetry (PIV) technique applied to micro-scale flow analysis ...
S. Błoński   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

The impact of a short squeeze through technical and fundamental analysis [PDF]

open access: yes, 2023
The GameStop short squeeze in January 2021, which was largely driven by retail traders on social media platforms, caused a significant increase in the stock prices of GameStop and AMC Entertainment.
Salovaara, Lasse
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Multitaper analysis of fundamental frequency variations during voiced fricatives

open access: yes, 2003
A method for tracking fundamental frequency variations in speech is proposed, based on multitaper analysis. Using the multitaper technique, a statistical test is developed for detecting the presence of harmonic components at multiples of a fundamental ...
Shadle, Christine H., Ramsay, Gordon
core  

Garage location selection for residential house by WASPAS-SVNS method

open access: yesJournal of Civil Engineering and Management, 2017
The paper deals with the location selection problem of the garage at the parcel of a single-family residential house. The mathematical model for this real life problem is constructed within MCDM framework.
Romualdas Baušys   +1 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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