Results 81 to 90 of about 1,298,480 (281)

The Last Scientific Revolution [PDF]

open access: yes, 2007
Critically growing problems of fundamental science organisation and content are analysed with examples from physics and emerging interdisciplinary fields.
Kirilyuk, Andrei
core   +4 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

open access: yes
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana   +8 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The skills mismatch: what doctoral candidates and employers consider important? [PDF]

open access: yes, 2011
The mobility of doctorate holders towards the non-academic labor market became of growing interest to policy-makers in and outside academia over the last decade.
De Boyser, Katrien   +3 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Fundamentalization of vocational education [PDF]

open access: yes
Аналізується суть фундаменталізації освіти як її спрямування на забезпечення учням узагальнених і універсальних знань, на формування в них загальної культури, узагальнених способів мислення і діяльності.
Гончаренко, Семен Устимович
core  

Theory and Practice of Data Citation

open access: yes, 2017
Citations are the cornerstone of knowledge propagation and the primary means of assessing the quality of research, as well as directing investments in science.
Silvello, Gianmaria
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

How to facilitate the implementation and diffusion of sustainable Product-Service Systems? Looking for synergies between strategic design and innovation sciences [PDF]

open access: yes, 2010
Copyright @ 2010 Greenleaf PublishingEco-efficient Product-Service System (PSS) innovations represent a promising approach to sustainability. However the application of this concept is still very limited because eco-efficient PSS are intrinsically ...
Ceschin, F
core  

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