Results 101 to 110 of about 8,567,027 (419)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

An Introduction to Hedge Funds [PDF]

arXiv, 2009
This report was originally written as an industry white paper on Hedge Funds. This paper gives an overview to Hedge Funds, with a focus on risk management issues. We define and explain the general characteristics of Hedge Funds, their main investment strategies and the risk models employed.
arxiv  

Valuing knowledge transfer : a new approach to assessing the broader impact of higher education institutions [PDF]

, 2009
There is considerable policy interest in exploring the overall value of higher education to society and in how higher education can support wider economic growth and development through 'knowledge transfer' from higher education institutions.
Kelly, Ursula, McNicoll, Iain, Nuffield Foundation (Funder), Scottish Funding Council (Funder)   +3 more
core  

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Net Stable Funding Ratio: Impact on Funding Value Adjustment [PDF]

arXiv, 2017
In this paper we investigate the relationship between Funding Value Adjustment (FVA) and Net Stable Funding Ratio (NSFR). FVA is defined in a consistent way with NSFR such that the new framework of FVA monitors the costs due to keeping NSFR at an acceptable level, as well.
arxiv  

Pension Funding and the Economy: Would Proper Funding Cost Jobs? [PDF]

, 2015
There is an ongoing debate in policy circles about the appropriate accounting standards for public sector pension funds. There are major differences between the standard practice of most pension funds and the policies that are advocated by many academic ...
Dean Baker, Nick Buffie
core  

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Fund Characteristics and Performances of Socially Responsible Mutual Funds: Do ESG Ratings Play a Role? [PDF]

arXiv, 2018
This paper examines the risk-adjusted performance and differential fund flows for socially responsible mutual funds (SRMF). The results show that SRMF rated high on ESG, perform better than lower rated ESG funds during the period of economic crisis. The findings also show that low ESG rated SRMF had higher differential cash-flows than high rated ESG ...
arxiv  

Crowdfunding scientific research: Descriptive insights and correlates of funding success

PLoS ONE, 2018
Crowdfunding has gained traction as a mechanism to raise resources for entrepreneurial and artistic projects, yet there is little systematic evidence on the potential of crowdfunding for scientific research.
Henry Sauermann, C. Franzoni, Kourosh Shafi   +2 more
semanticscholar   +1 more source

The diversification benefits of hedge funds and funds of hedge funds [PDF]

Derivatives Use, Trading & Regulation, 2007
We examine whether investors can improve their investment opportunity set through the addition of a hedge fund (HF) or fund of HF portfolio to different sets of benchmark portfolios. Using data from 1994 to 2004, we find that HF, as an asset class, improve the mean–variance frontier of sets of benchmark portfolios sorted by firm size and book-to-market
openaire   +2 more sources