Results 101 to 110 of about 8,559,535 (341)

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

Purdue Road School: Funding, Funding, Funding

open access: yes, 2013
Municipal entities are facing many issues which are causing financial distress. This presentation will discuss strategies to assist in these difficult times. The strategies to be discussed will include short and long-term financial planning, board discussions and the creation of a capital improvement plan.
openaire   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Public Policy and Funding the News [PDF]

open access: yes, 2010
Illustrates how declining government support and recent regulatory decisions have affected the viability of periodicals and other news outlets. Proposes a policy framework for indirect, content-neutral funding and investment in innovation and new ...
David Westphal, Geoffrey Cowan
core  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Consent for further education colleges to invest in companies [PDF]

open access: yes, 2011
Summary: This guidance document is aimed at college principals and finance directors as well as staff within the Skills Funding Agency. It lays out the requirements for Further Education (FE) colleges to seek Skills Funding Agency (the Agency) consent to

core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Assessing tourism as a catalyst for rural development and community awareness: A case study of Coffee Bay, Mqanduli in the Eastern Cape Province. [PDF]

open access: yesAfrican Journal of Hospitality, Tourism and Leisure, 2019
The aim of this paper is to assess tourism as a catalyst for rural development and community awareness in a case study of Coffee Bay. Tourism is considered as a viable tool for economic development, specifically in the developing world.
Prof Dinesh Vallabh, Sakhumzi Woyikani
doaj  

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