Results 111 to 120 of about 8,567,027 (419)
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Characterization, description, and considerations for the use of funding acknowledgement data in Web of Science [PDF]
, 2016 Funding acknowledgements found in scientific publications have been used to study the impact of funding on research since the 1970s. However, no broad scale indexation of that paratextual element was done until 2008, when Thomson Reuters Web of Science started to add funding acknowledgement information to its bibliographic records.
arxiv +1 more source
Public use and public funding of science
Nature Human Behaviour, 2022 Yian Yin +4 more
semanticscholar +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Funding Research Through the Online Partnership to Accelerate Research (OnPAR)
JACC: Basic to Translational Science, 2016 OnPAR—the Online Partnership to Accelerate Research—seeks to provide a second opportunity for funding of high-quality, unfunded applications originally submitted to the National Institutes of Health and other national and international funding agencies ...
Martin A. Dueñas, MPA +1 more
doaj +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Activitatea de cercetare din România - prezent, modalităţi de reformare şi finanţare [PDF]
Urbanism. Arhitectura. Constructii, 2013 Scientific research represents today the most important lever for improving the living standard, health, culture and, in general, the wealth of a society.
Mircea-Iosif Rus
doaj
Hedge and Mutual Funds' Fees and the Separation of Private Investments [PDF]
arXiv, 2012 A fund manager invests both the fund's assets and own private wealth in separate but potentially correlated risky assets, aiming to maximize expected utility from private wealth in the long run. If relative risk aversion and investment opportunities are constant, we find that the fund's portfolio depends only on the fund's investment opportunities, and
arxiv
Skills Funding Agency : a new streamlined funding system for adult skills [PDF]
, 2011 "This document provides an update to the further education (FE) sector on the Skills Funding Agency’s progress with simplifying the adult skills funding system" -- front ...
core