Results 171 to 180 of about 5,455,581 (314)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Banks' wholesale funding and credit procyclicality: evidence from Korea

open access: yes
Credit procyclicality has recently been the focus of considerable attention, but what fuels the often excessive credit growth is rarely questioned.
Jeong, Sangjun, Jung, Hueechae
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

The Effects of Congressional Appropriation Committee Membership on the Distribution of Federal Research Funding to Universities [PDF]

open access: yes
This paper examines the impact of congressional representation of a university through district representation or an alma mater affiliation on the distribution of research funding to research and doctoral universities in the United States.
A Abigail Payne
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Funding Dilemma in Pakistani Libraries: Causes, Effects, Responses

open access: yes, 2006
Literature on funding problems of Pakistani libraries reveals that poor economy of the country, inflation, low priority to education and price increase of library material are the main causes of this dilemma.
Hameed, Abdul   +2 more
core  

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