Results 41 to 50 of about 171,170 (252)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Corneal stromal lenticule transplantation for the treatment of congenital optic disc pit maculopathy : a case report and review

BMC Ophthalmology
Background Congenital optic disc pit (ODP) is a relatively uncommon congenital anomaly of the optic disc, which seriously affects the patient’s vision when combined with optic disc pit maculopathy(ODP-M).
Xiaojuan Zhang, Gang Qiao, Yu Quan, Yukun He, Hui Jiang   +4 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

High BMI, silicone oil tamponade, and recurrent vitreous hemorrhage predict poor visual outcomes after pars plana vitrectomy in proliferative diabetic retinopathy

BMC Ophthalmology
Background Proliferative diabetic retinopathy (PDR) is a serious microvascular complication of diabetes and a leading cause of global vision loss. Pars plana vitrectomy (PPV) is the primary surgical treatment for PDR, but visual outcomes vary due to ...
Zhi-gang Wang, Ping Li, Xiu-min Yang, Zi-qi Wang, Pei-ran Zhang   +4 more
doaj   +1 more source

Investigation of algorithms for coagulate arrangement in fundus images [PDF]

Компьютерная оптика, 2018
Diabetic retinopathy is one of the most frequent complications of diabetes, which leads to severe consequences, including rapid and irreversible vision loss.
Aleksandr Shirokanev, Dmitriy Kirsh, Nataly Ilyasova , Alexandr Kupriyanov   +3 more
doaj   +1 more source

An Update on Multimodal Ophthalmological Imaging of Diffuse Choroidal Hemangioma in Sturge–Weber Syndrome

Vision, 2023
Sturge–Weber syndrome (SWS) is characterized by facial port-wine stains, leptomeningeal hemangiomas, and prominent ocular manifestations such as glaucoma and diffuse choroidal hemangiomas (DCHs).
Chiara Ciancimino, Mariachiara Di Pippo, Daria Rullo, Francesco Ruggeri, Flaminia Grassi, Gianluca Scuderi, Solmaz Abdolrahimzadeh   +6 more
doaj   +1 more source

An Injectable, Self‐Expanding Hemostatic Foam for Field‐Compatible Postpartum Hemorrhage Management

Advanced Science, EarlyView.
Postpartum hemorrhage is the leading cause of maternal death worldwide, yet many treatments are hard to use outside well‐equipped hospitals. This work introduces an easy‐to‐use device that rapidly delivers a degradable foam into the uterus. The foam stops bleeding through pressure and clotting support, offering a practical option for low‐resource ...
Charlotte Meyer, Noël Strasser, Ilakkiya Ravindrarajah, Elsa Wrenger, Kristian Ivkovic, Jan Ševčík, Sima Šarčević, Lenka Červenková, Jáchym Rosendorf, Václav Liška, Alexandre H. Anthis, Thomas Rduch, Inge K. Herrmann   +12 more
wiley   +1 more source

L'habitat des élites romaines dans les suburbia d'Aquitaine méridionale : approches géographiques et morphologiques

Fundus
Comment définir les aires suburbaines ? Peut-on identifier un modèle type ? Existe-t-il un ensemble de marqueurs suffisamment pertinents pour essayer de systématiser le processus d’identification dans les différentes provinces de l’Empire romain ...
Sébastien Cabes, Benoit Pace
doaj   +1 more source

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Civitati, fluvio, mari proximus: occupation de l’espace fluvio-lagunaire autour de Narbonne (Narbo Martius/Narbona) durant l’Antiquité tardive (fin IIIe - début VIIIe siècle ap. J.-C.)

Fundus
La microrégion fluvio-lagunaire au sud et à l’est de Narbo Martius/Narbona (Narbonne, Aude) est un espace particulier revêtant certains aspects suburbains du fait d’accueillir le système portuaire de la ville antique.
Lyubomir Malinov
doaj   +1 more source