Results 71 to 80 of about 12,477 (204)

Macular telangiectasia type 2 genetic risk variants associated with clinical characteristics in the Slovenian cohort

Acta Ophthalmologica, EarlyView.
Abstract Purpose Early diagnosis of macular telangiectasia type 2 (MacTel) remains challenging, and the contribution of genetic variation to its clinical heterogeneity is unclear. This study investigated associations between MacTel risk variants and clinical characteristics in a Slovenian cohort.
Ajda Kunčič, Nataša Debeljak, Petra Hudler, Janez Smerkolj, Mojca Urbančič   +4 more
wiley   +1 more source

Systematic quantification of outer retinal morphology in three different SD‐OCT devices in geographic atrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To define interdevice differences in quantitative outer retinal biomarkers across three spectral‐domain (SD) optical coherence tomography (OCT) devices in geographic atrophy (GA). Methods Patients with GA prospectively underwent imaging using Spectralis (Heidelberg Engineering), Cirrus (Zeiss) and Maestro (Topcon) OCT devices ...
Klaudia Birner, Sophie Frank‐Publig, Julia Mai, Anna Eidenberger, Johannes Schrittwieser, Gabriel Leitner‐Barrios, Magdalena Barasits, Markus Gumpinger, Gregor S. Reiter, Stefan Sacu, Ursula Schmidt‐Erfurth   +10 more
wiley   +1 more source

Clinical and molecular features of PRCD‐associated retinopathy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To describe the clinical and genetic characteristics of patients with biallelic disease‐causing variants in the PRCD (Progressive Rod‐Cone Degeneration) gene. Methods Multicentre, retrospective cohort study of 19 patients from 13 families across nine reference centres in six countries.
Vasil Kostin, Karolina Kaminska, Marco Cattaneo, Enrico Ambrosini, Carmen Ayuso, Almudena Ávila‐Fernández, Béatrice Bocquet, Luisa Coutinho‐Santos, Benedetto Falsini, Lidia Fernandez‐Caballero Palomeque, Bohdan Kousal, Petra Liskova, Inmaculada Martín‐Mérida, María Juliana Ballesta‐Martínez, Daan Panneman, Susanne Roosing, Isabelle Meunier, José M. Millán, Monika Pankievič, Irene Perea‐Romero, Virginie Peter, Giorgio Placidi, Cristina Santos, Francesca Simonelli, Ana Berta Sousa, Francesco Testa, Marie Vajter, Marianna Weener, Mathieu Quinodoz, Carlo Rivolta, Giacomo Calzetti   +30 more
wiley   +1 more source

Evaluation of fundus autofluorescence imaging of diabetic patients without retinopathy [PDF]

, 2019
Purpose: To evaluate the usefulness of fundus autofluorescence imaging of diabetic patients without retinopathy to investigate early retinal damage. Methods: Fundus autofluorescence images of patients with type 2 diabetes mellitus without retinopathy ...
Sumeyra Agca, Özkan Aksoy, Nilgün, Gursoy Alagoz, Vildan Sonalcan, Sedat Ozmen, Emine Dogan, Çakır, Burçin   +6 more
core   +1 more source

Regional growth kinetics of geographic atrophy in age‐related macular degeneration with and without fovea‐sparing

Acta Ophthalmologica, EarlyView.
Abstract Purpose Fovea‐sparing geographic atrophy (GA) patients retain near‐normal central vision. To better understand GA progression in relation to the fovea, we performed a semi‐automated image analysis of regional atrophy growth in a long‐term GA natural‐history cohort. Methods Prospective‐observational, single‐centre‐study (02/2013–07/2025) at the
Daniel R. Muth, Abinaya P. Venkataraman, Alberto Dominguez‐Vicent, Goran Petrovski, Pete A. Williams, Laurence Quérat, Filippo Locri, Sandrine A. Zweifel, Anders Kvanta   +8 more
wiley   +1 more source

Recovery of outer retina in acute idiopathic blind spot enlargement (AIBSE)

American Journal of Ophthalmology Case Reports, 2016
Purpose: To report the anatomic and functional recovery of the ellipsoid zone in a case of acute idiopathic blind spot enlargement (AIBSE), which was documented by serial high-resolution optical coherence tomography imaging.
Matthew G.J. Trese, Steven R. Cohen, Cagri G. Besirli   +2 more
doaj   +1 more source

CRB1‐Associated Inherited Retinal Dystrophies: Prospective Natural History Study With 4 Years of Follow‐Up

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background The lack of validated and sensitive clinical endpoints remains a major challenge in the design of gene therapy trials for inherited retinal dystrophies (IRDs). This prospective longitudinal cohort study describes the natural disease progression of IRDs caused by pathogenic mutations in the Crumbs homologue 1 (CRB1) gene, and ...
Jessica S. Karuntu, Xuan‐Thanh‐An Nguyen, Mays Talib, Mary J. van Schooneveld, Jan Wijnholds, Maria M. van Genderen, Jos Twisk, Nicoline E. Schalij‐Delfos, Caroline C. W. Klaver, Ralph J. Florijn, Jacoline B. ten Brink, Magda A. Smoor, L. Ingeborgh van den Born, Carel B. Hoyng, Alberta A. H. J. Thiadens, Camiel J. F. Boon   +15 more
wiley   +1 more source

Evaluation of fundus autofluorescence ımaging of diabetic patients without retinopathy [PDF]

, 2019
Purpose: To evaluate the usefulness of fundus autofluorescence imaging of diabetic patients without retinopathy to investigate early retinal damage. Methods: Fundus autofluorescence images of patients with type 2 diabetes mellitus without retinopathy ...
Sümeyra Ağca (7368305), Emine Doğan (5760773), Nilgün Özkan Aksoy (7368308), Burçin Çakır (6209513), Gürsoy Alagöz (6209522), Sedat Özmen (7368302), Vildan Sonalcan (7368311)   +6 more
core   +1 more source

Epiretinal membrane surgery for combined hamartoma of the retina and retinal pigment epithelium: role of multimodal analysis

Clinical Ophthalmology, 2013
Claudia Bruè, Andrea Saitta, Michele Nicolai, Cesare Mariotti, Alfonso GiovanniniOphthalmology, Department of Neuroscience, Marche Polytechnic University, Ancona, ItalyBackground: The purpose of this study was to evaluate the role of spectral ...
Bruè C, Saitta A, Nicolai M, Mariotti C, Giovannini A   +4 more
doaj  

Randomised Clinical Trial to Evaluate the Efficacy of Acetazolamide for the Treatment of Cystoid Fluid Collections in X‐Linked Retinoschisis: The AXIS Trial

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background This trial aimed to evaluate the efficacy of oral acetazolamide in reducing cystoid fluid collections (CFC) and improving visual function in patients with X‐linked retinoschisis (XLRS). Methods In this investigator‐initiated, single centre, open‐label, randomised controlled trial, XLRS patients aged ≥ 12 years with fovea‐involving ...
Jonathan Hensman, Hind Almushattat, Roselie M. H. Diederen, Tien‐En Tan, Peilun Dai, Coen de Vente, Daniel S. W. Ting, Maria M. van Genderen, Jeannette Ossewaarde‐van Norel, Redmer van Leeuwen, Martha J. H. Tjon‐Fo‐Sang, Clara I. Sánchez, M. Dominik Fischer, Maximilian Pfau, Jos W. R. Twisk, Camiel J. F. Boon   +15 more
wiley   +1 more source