Lipofuscin, lipofuscin-like pigments and autofluorescence
European Journal of Histochemistry, 2015 A brief overview is here provided on lipofuscin and lipofuscin-like substances, with particular reference to their biological significance as well as to their cellular origin and pathophysiological role.
G. Di Guardo
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Lipofuscin accumulation in aging and neurodegeneration: a potential “timebomb” overlooked in Alzheimer’s disease [PDF]
Translational NeurodegenerationLipofuscin, a marker of aging, is the accumulation of autofluorescent granules within microglia and postmitotic cells such as neurons. Lipofuscin has traditionally been regarded as an inert byproduct of cellular degradation.
Godfried Dougnon, Hideaki Matsui
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Age, lipofuscin and melanin oxidation affect fundus near-infrared autofluorescence
EBioMedicine, 2019 Background: Fundus autofluorescence is a non-invasive imaging technique in ophthalmology. Conventionally, short-wavelength autofluorescence (SW-AF) is used for detection of lipofuscin, a byproduct of the visual cycle which accumulates with age or disease
Tatjana Taubitz +2 more
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Histochemical characteristics and distribution of lipofuscin and polyglucosan bodies in the brain of dogs more than 10 years old [PDF]
Veterinarski Glasnik, 2021 The ageing process is accompanied by numerous changes in the brain of dogs, such as accumulation of amyloid, fibrosis of blood vessel walls and meninges, accumulation of lipofuscin, and the presence of polyglucosan bodies (PGBs), satellitosis and ...
Nešić Slađan +7 more
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Antioxidants, 2023 Lipofuscin of retinal pigment epithelium (RPE) cells is a complex heterogeneous system of chromophores which accumulates as granules during the cell’s lifespan.
Alexey N. Semenov +11 more
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Patterns of lipofuscin accumulation in ganglionic nerve cells of superior cervical ganglion in humans [PDF]
Vojnosanitetski Pregled, 2008 Background/Aim. Considering available literature lipofuscin is a classical age pigment of postmitotic cells, and a consistently recognized phenomenon in humans and animals.
Živković Vladimir +7 more
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Antioxidants, 2023 Lipofuscin accumulates with age as intracellular fluorescent granules originating from incomplete lysosomal digestion of phagocytosed and autophagocytosed material.
Małgorzata B. Różanowska
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Preliminary identification and quantification of the age-pigment lipofuscin in the brain of Farfantepenaeus paulensis (Crustacea: Decapoda) [PDF]
Brazilian Journal of Biology, 2002 A preliminary study was done on the age-pigment lipofuscin content in the brains of captive Farfantepenaeus paulensis juveniles (5 months old) and wild adults (estimated age of 12-15 months). Random samples of 6 individuals were obtained from each group (
S. Peixoto +4 more
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Scientific Reports, 2021 Melanosomes, lipofuscin, and melanolipofuscin are the three principal types of pigmented granules found in retinal pigment epithelium (RPE) cells. Changes in the density of melanosomes and lipofuscin in RPE cells are considered hallmarks of various ...
Ratheesh K. Meleppat +5 more
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The 5HT1a receptor agonist 8-Oh DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium. [PDF]
PLoS ONE, 2012 Age-related macular degeneration (AMD), a major cause of blindness in the elderly, is associated with oxidative stress, lipofuscin accumulation and retinal degeneration.
Prajitha Thampi +10 more
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