Results 11 to 20 of about 18,102 (192)

Lipofuscin accumulation in aging and neurodegeneration: a potential “timebomb” overlooked in Alzheimer’s disease [PDF]

Translational Neurodegeneration
Lipofuscin, a marker of aging, is the accumulation of autofluorescent granules within microglia and postmitotic cells such as neurons. Lipofuscin has traditionally been regarded as an inert byproduct of cellular degradation.
Godfried Dougnon, Hideaki Matsui
exaly   +3 more sources

Lipofuscin: Wear Pigment or Alarm Signal for Cardiac AlloGraft Vasculopathy? [PDF]

Diagnostics
Background: CAV (cardiac allograft vasculopathy) is considered the leading cause of late post-transplant mortality and affects approximately 50% of transplant patients at 10 years post-transplant. Its etiopathogenetic mechanism is considered to be immune-
Anca Otilia Farcas, Mihai Ciprian Stoica, Septimiu Voidazan, Carmen Corina Radu, Laszlo Hadadi, Liviu Gavrilovici, Horatiu Suciu, Anca Ileana Sin   +7 more
doaj   +2 more sources

Lipofuscin, lipofuscin-like pigments and autofluorescence

European Journal of Histochemistry, 2015
A brief overview is here provided on lipofuscin and lipofuscin-like substances, with particular reference to their biological significance as well as to their cellular origin and pathophysiological role.
G. Di Guardo
doaj   +5 more sources

Age, lipofuscin and melanin oxidation affect fundus near-infrared autofluorescence

EBioMedicine, 2019
Background: Fundus autofluorescence is a non-invasive imaging technique in ophthalmology. Conventionally, short-wavelength autofluorescence (SW-AF) is used for detection of lipofuscin, a byproduct of the visual cycle which accumulates with age or disease
Sylvie Julien-Schraermeyer, Antje Biesemeier, Tatjana Taubitz   +2 more
exaly   +3 more sources

Mitochondrial contribution to lipofuscin formation

Redox Biology, 2017
Mitochondria have been in the focus of oxidative stress and aging research for decades due to their permanent production of ROS during the oxidative phosphorylation.
Jeannette König, Christiane Ott, Martín Hugo, Tobias Jung, Anne-Laure Bulteau, Tilman Grune, Annika Höhn   +6 more
doaj   +3 more sources

Histochemical characteristics and distribution of lipofuscin and polyglucosan bodies in the brain of dogs more than 10 years old [PDF]

Veterinarski Glasnik, 2021
The ageing process is accompanied by numerous changes in the brain of dogs, such as accumulation of amyloid, fibrosis of blood vessel walls and meninges, accumulation of lipofuscin, and the presence of polyglucosan bodies (PGBs), satellitosis and ...
Nešić Slađan, Vučićević Ivana, Marinković Darko, Kukolj Vladimir, Aničić Milan, Ristoski Trpe, Nikolić Sonja, Aleksić-Kovačević Sanja   +7 more
doaj   +1 more source

Protein-Mediated Carotenoid Delivery Suppresses the Photoinducible Oxidation of Lipofuscin in Retinal Pigment Epithelial Cells

Antioxidants, 2023
Lipofuscin of retinal pigment epithelium (RPE) cells is a complex heterogeneous system of chromophores which accumulates as granules during the cell’s lifespan.
Alexey N. Semenov, Eugene G. Maksimov, Anastasia M. Moysenovich, Marina A. Yakovleva, Georgy V. Tsoraev, Alla A. Ramonova, Evgeny A. Shirshin, Nikolai N. Sluchanko, Tatiana B. Feldman, Andrew B. Rubin, Mikhail P. Kirpichnikov, Mikhail A. Ostrovsky   +11 more
doaj   +1 more source

Patterns of lipofuscin accumulation in ganglionic nerve cells of superior cervical ganglion in humans [PDF]

Vojnosanitetski Pregled, 2008
Background/Aim. Considering available literature lipofuscin is a classical age pigment of postmitotic cells, and a consistently recognized phenomenon in humans and animals.
Živković Vladimir, Stefanović Natalija, Đurović-Filipović Tatjana, Pavlović Snežana, Stojanović Vesna, Bakić Mirjana, Kundalić Braca, Pavlović Miljana   +7 more
doaj   +1 more source

Lipofuscin, Its Origin, Properties, and Contribution to Retinal Fluorescence as a Potential Biomarker of Oxidative Damage to the Retina

Antioxidants, 2023
Lipofuscin accumulates with age as intracellular fluorescent granules originating from incomplete lysosomal digestion of phagocytosed and autophagocytosed material.
Małgorzata B. Różanowska
doaj   +1 more source

Preliminary identification and quantification of the age-pigment lipofuscin in the brain of Farfantepenaeus paulensis (Crustacea: Decapoda) [PDF]

Brazilian Journal of Biology, 2002
A preliminary study was done on the age-pigment lipofuscin content in the brains of captive Farfantepenaeus paulensis juveniles (5 months old) and wild adults (estimated age of 12-15 months). Random samples of 6 individuals were obtained from each group (
S. Peixoto, N. Aguado, F. D'Incao, W. Wasielesky, J. C. Cousin   +4 more
doaj   +1 more source