Lipofuscin: The Missing Link in the Worsening of Obstructive Sleep Apnea. [PDF]
LaryngoscopeLipofuscin, also known as the age pigment, is a permanent autofluorescent intracellular deposit that accumulates with aging or oxidative stress, thereby interfering with cellular function. This study revealed significantly larger deposits of lipofuscin in the lateral pharyngeal wall muscles of patients with severe obstructive sleep apnea (OSA) compared
Fahl K +7 more
europepmc +2 more sources
Preliminary identification and quantification of the age-pigment lipofuscin in the brain of Farfantepenaeus paulensis (Crustacea: Decapoda) [PDF]
Brazilian Journal of Biology, 2002 A preliminary study was done on the age-pigment lipofuscin content in the brains of captive Farfantepenaeus paulensis juveniles (5 months old) and wild adults (estimated age of 12-15 months). Random samples of 6 individuals were obtained from each group (
S. Peixoto +4 more
doaj +1 more source
Scientific Reports, 2021 Melanosomes, lipofuscin, and melanolipofuscin are the three principal types of pigmented granules found in retinal pigment epithelium (RPE) cells. Changes in the density of melanosomes and lipofuscin in RPE cells are considered hallmarks of various ...
Ratheesh K. Meleppat +5 more
doaj +1 more source
Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins [PDF]
, 2020 Background Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown, it has been hypothesized that haploinsufficiency might be involved in the ...
Aramburu, Ana +13 more
core +2 more sources
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo. [PDF]
, 2015 Lysosomes are classically viewed as vesicular structures to which cargos are delivered for degradation. Here, we identify a network of dynamic, tubular lysosomes that extends throughout Drosophila muscle, in vivo. Live imaging reveals that autophagosomes
Davis, Graeme W +4 more
core +3 more sources
The 5HT1a receptor agonist 8-Oh DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium. [PDF]
PLoS ONE, 2012 Age-related macular degeneration (AMD), a major cause of blindness in the elderly, is associated with oxidative stress, lipofuscin accumulation and retinal degeneration.
Prajitha Thampi +10 more
doaj +1 more source
Photo-damage, photo-protection and age-related macular degeneration [PDF]
, 2015 Age-related macular degeneration (AMD) is a degenerative retinal disease that causes blindness in people 60-65 years and older, with the highest prevalence appearing in people 90 years-old or more.
Marquioni Ramella, Melisa Daniela +1 more
core +1 more source
Progressive retinal degeneration and glial activation in the Cln6nclf mouse model of neuronal ceroid lipofuscinosis : a beneficial effect of DHA and Curcumin supplementation [PDF]
, 2013 Neuronal ceroid lipofuscinosis (NCL) is a group of neurodegenerative lysosomal storage disorders characterized by vision loss, mental and motor deficits, and spontaneous seizures.
Jägle, Herbert +9 more
core +2 more sources
Frontal lobe epilepsy with focal neuronal lipofuscinosis – Case report of a rare entity
Epilepsy & Behavior Reports, 2020 Focal neuronal lipofuscinosis is a unique neuronal pathology, characterised by accumulation of lipofuscin within dysmorphic neurons. We report a case of 12-year-old female with drug resistant epilepsy since one and a half years of age.
Radhika Mhatre +5 more
doaj +1 more source