Results 41 to 50 of about 17,675 (181)

Oxidized protein aggregate lipofuscin impairs cardiomyocyte contractility via late-stage autophagy inhibition

Redox Biology
Aging of the heart is accompanied by impairment of cardiac structure and function. At molecular level, autophagy plays a crucial role in preserving cardiac health.
Sophia Walter, Steffen P. Häseli, Patricia Baumgarten, Stefanie Deubel, Tobias Jung, Annika Höhn, Christiane Ott, Tilman Grune   +7 more
doaj   +1 more source

Melanoma and Other Melanistic Lesions in Brown Bullhead Ameiurus nebulosus From Waterbodies in the Northeastern United States and Canada: Identification of Risk Factors

Journal of Fish Diseases, EarlyView.
ABSTRACT Melanistic lesions, including non‐raised black areas due to proliferations of melanocytes and melanomacrophages in the dermis and epidermis, as well as raised black areas consistent with melanoma, are described in brown bullhead (BBH) Ameiurus nebulosus from three water bodies in the northeastern United States and Quebec, Canada.
Vicki S. Blazer, Peter Emerson, Matthew Bodnar, Thomas Jones, David R. Russell, Matthew Pehrson, Cheyenne R. Smith, Danielle Cleveland, Mark J. Henderson, Patricia M. Mazik   +9 more
wiley   +1 more source

Fundus autofluorescence applications in retinal imaging

Indian Journal of Ophthalmology, 2015
Fundus autofluorescence (FAF) is a relatively new imaging technique that can be used to study retinal diseases. It provides information on retinal metabolism and health. Several different pathologies can be detected.
Andrea Gabai, Daniele Veritti, Paolo Lanzetta   +2 more
doaj   +1 more source

Ocular Manifestations of Infectious Salmon Anaemia Virus Infection in Atlantic Salmon (Salmo salar)

Journal of Fish Diseases, EarlyView.
ABSTRACT Eyes are essential sensory organs needed by teleost Atlantic salmon for high visual acuity and survival in both the wild and in aquaculture settings. In this work, we assessed the ocular manifestations of Infectious Salmon Anaemia Virus (ISAV) infection in Atlantic salmon by a cohabitation‐mediated infection assay and histological and ...
Emily Mahon, Rebecca R. Kwabiah, Hélène Paradis, Manuel A. Soto‐Dávila, Sathees Duglas, Raja Ram Gurung, Thurka Paramanathan, Ignacio Vasquez, Shams Al‐Badoosh, John Law, Javier Santander, Mark D. Fast, Robert L. Gendron   +12 more
wiley   +1 more source

A2E: A Component of Ocular Lipofuscin¶ [PDF]

Photochemistry and Photobiology, 2004
ABSTRACTThe presence of lipofuscin in post mitotic cells is considered a hallmark of the aging process. In the retinal pigment epithelium (RPE), lipofuscin is found as micrometer‐sized spherical particles and characterized by its yellow autofluorescence when exposed to blue light.
Laura E, Lamb, John D, Simon
openaire   +2 more sources

Temporary Vitelliform Regression After Intravitreal Ranibizumab Injection for Macular Neovascularization Complicating Best Disease

International Medical Case Reports Journal, 2022
Alaa Fayed1,2 1Department of Ophthalmology, Kasr Al-Ainy School of Medicine, Cairo University, Giza, Egypt; 2Watany Research and Development Center, Watany Eye Hospital, Cairo, EgyptCorrespondence: Alaa Fayed, Department of Ophthalmology, Kasr Al-Ainy ...
Fayed A
doaj  

Macular edema in Asian Indian premature infants with retinopathy of prematurity: Impact on visual acuity and refractive status after 1-year

Indian Journal of Ophthalmology, 2015
Purpose: To report the impact of transient, self-resolving, untreated "macular edema" detected on spectral domain optical coherence tomography in Asian Indian premature infants with retinopathy of prematurity (ROP) on visual acuity (VA) and refraction at
Anand Vinekar, Shwetha Mangalesh, Chaitra Jayadev, Noel Bauer, Sivakumar Munusamy, Vasudha Kemmanu, Mathew Kurian, Padmamalini Mahendradas, Kavitha Avadhani, Bhujang Shetty   +9 more
doaj   +1 more source

Pulmonary alveolar proteinosis after lung transplantation

Respirology Case Reports, 2020
We report the case of a 69‐year‐old man five‐month post double lung transplant for idiopathic pulmonary fibrosis (IPF) who presented with progressive breathlessness, loss of lung function, and diffuse ground glass shadowing on the chest computed ...
Chandima Divithotawela, Simon H. Apte, Maxine E. Tan, Tharushi A. De Silva, Daniel C. Chambers   +4 more
doaj   +1 more source

Orchestrated molecular changes of proliferative, migratory‐fibrillar, synaptic, and postmigratory compartments align with precocious cortex‐type specification in the early human pallium

Journal of Anatomy, EarlyView.
Early human cortical development is organized by transient cellular compartments that define cortical types before mature layers form. Analysis of the human fetal pallium (7.5–15 PCW) shows distinct spatiotemporal trajectories for the archicortex, mesocortex, and neocortex, with delayed but accelerated differentiation in allocortical regions.
Janja Kopić, Fran Božić, Alisa Junaković Munjas, Željka Krsnik, Ivica Kostović   +4 more
wiley   +1 more source

Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality

Medicina, 2020
Intra-lysosomal accumulation of the autofluorescent “residue” known as lipofuscin, which is found within postmitotic cells, remains controversial. Although it was considered a harmless hallmark of aging, its presence is detrimental as it continually ...
Ovidiu-Dumitru Ilie, Alin Ciobica, Sorin Riga, Nitasha Dhunna, Jack McKenna, Ioannis Mavroudis, Bogdan Doroftei, Adela-Magdalena Ciobanu, Dan Riga   +8 more
doaj   +1 more source