Results 41 to 50 of about 17,764 (195)

Crosstalk between the Rod Outer Segments and Retinal Pigmented Epithelium in the Generation of Oxidative Stress in an In Vitro Model

Cells, 2023
Dysfunction of the retinal pigment epithelium (RPE) is associated with several diseases characterized by retinal degeneration, such as diabetic retinopathy (DR).
Silvia Ravera, Nadia Bertola, Alessandra Puddu, Silvia Bruno, Davide Maggi, Isabella Panfoli   +5 more
doaj   +1 more source

Junctional sensitivity and atrophy progression rate of geographic atrophy secondary to age‐related macular degeneration

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the relationship between the baseline junctional retinal sensitivity measured with microperimetry and the atrophy progression rate in eyes with geographic atrophy (GA) secondary to age‐related macular degeneration. Methods In this prospective cohort study, patients with GA were examined with fundus autofluorescence (FAF ...
Alexander Kai Thomsen, Jenni Martinez Villarruel Hinnerskov, Miranda Maung, Aubin Mutschler, SriniVas Sadda, Torben Lykke Sørensen   +5 more
wiley   +1 more source

Oxidized protein aggregate lipofuscin impairs cardiomyocyte contractility via late-stage autophagy inhibition

Redox Biology
Aging of the heart is accompanied by impairment of cardiac structure and function. At molecular level, autophagy plays a crucial role in preserving cardiac health.
Sophia Walter, Steffen P. Häseli, Patricia Baumgarten, Stefanie Deubel, Tobias Jung, Annika Höhn, Christiane Ott, Tilman Grune   +7 more
doaj   +1 more source

Retinal dystrophies simulating geographic atrophy: A diagnostic challenge

Acta Ophthalmologica, EarlyView.
Abstract Geographic atrophy (GA) is the chronic loss of retinal pigment epithelium, photoreceptors and choriocapillaris, marking the dry late stage of age‐related macular degeneration (AMD). GA prevalence is expected to rise in the upcoming decades. Advanced GA leads to central scotomas, reducing visual acuity and quality of life, potentially resulting
Johanna M. Colijn, Frank G. Holz, Jeroen Pas, Carel Hoyng   +3 more
wiley   +1 more source

Clinical and molecular features of PRCD‐associated retinopathy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To describe the clinical and genetic characteristics of patients with biallelic disease‐causing variants in the PRCD (Progressive Rod‐Cone Degeneration) gene. Methods Multicentre, retrospective cohort study of 19 patients from 13 families across nine reference centres in six countries.
Vasil Kostin, Karolina Kaminska, Marco Cattaneo, Enrico Ambrosini, Carmen Ayuso, Almudena Ávila‐Fernández, Béatrice Bocquet, Luisa Coutinho‐Santos, Benedetto Falsini, Lidia Fernandez‐Caballero Palomeque, Bohdan Kousal, Petra Liskova, Inmaculada Martín‐Mérida, María Juliana Ballesta‐Martínez, Daan Panneman, Susanne Roosing, Isabelle Meunier, José M. Millán, Monika Pankievič, Irene Perea‐Romero, Virginie Peter, Giorgio Placidi, Cristina Santos, Francesca Simonelli, Ana Berta Sousa, Francesco Testa, Marie Vajter, Marianna Weener, Mathieu Quinodoz, Carlo Rivolta, Giacomo Calzetti   +30 more
wiley   +1 more source

Fundus autofluorescence applications in retinal imaging

Indian Journal of Ophthalmology, 2015
Fundus autofluorescence (FAF) is a relatively new imaging technique that can be used to study retinal diseases. It provides information on retinal metabolism and health. Several different pathologies can be detected.
Andrea Gabai, Daniele Veritti, Paolo Lanzetta   +2 more
doaj   +1 more source

Regional growth kinetics of geographic atrophy in age‐related macular degeneration with and without fovea‐sparing

Acta Ophthalmologica, EarlyView.
Abstract Purpose Fovea‐sparing geographic atrophy (GA) patients retain near‐normal central vision. To better understand GA progression in relation to the fovea, we performed a semi‐automated image analysis of regional atrophy growth in a long‐term GA natural‐history cohort. Methods Prospective‐observational, single‐centre‐study (02/2013–07/2025) at the
Daniel R. Muth, Abinaya P. Venkataraman, Alberto Dominguez‐Vicent, Goran Petrovski, Pete A. Williams, Laurence Quérat, Filippo Locri, Sandrine A. Zweifel, Anders Kvanta   +8 more
wiley   +1 more source

Temporary Vitelliform Regression After Intravitreal Ranibizumab Injection for Macular Neovascularization Complicating Best Disease

International Medical Case Reports Journal, 2022
Alaa Fayed1,2 1Department of Ophthalmology, Kasr Al-Ainy School of Medicine, Cairo University, Giza, Egypt; 2Watany Research and Development Center, Watany Eye Hospital, Cairo, EgyptCorrespondence: Alaa Fayed, Department of Ophthalmology, Kasr Al-Ainy ...
Fayed A
doaj  

Macular edema in Asian Indian premature infants with retinopathy of prematurity: Impact on visual acuity and refractive status after 1-year

Indian Journal of Ophthalmology, 2015
Purpose: To report the impact of transient, self-resolving, untreated "macular edema" detected on spectral domain optical coherence tomography in Asian Indian premature infants with retinopathy of prematurity (ROP) on visual acuity (VA) and refraction at
Anand Vinekar, Shwetha Mangalesh, Chaitra Jayadev, Noel Bauer, Sivakumar Munusamy, Vasudha Kemmanu, Mathew Kurian, Padmamalini Mahendradas, Kavitha Avadhani, Bhujang Shetty   +9 more
doaj   +1 more source

Pulmonary alveolar proteinosis after lung transplantation

Respirology Case Reports, 2020
We report the case of a 69‐year‐old man five‐month post double lung transplant for idiopathic pulmonary fibrosis (IPF) who presented with progressive breathlessness, loss of lung function, and diffuse ground glass shadowing on the chest computed ...
Chandima Divithotawela, Simon H. Apte, Maxine E. Tan, Tharushi A. De Silva, Daniel C. Chambers   +4 more
doaj   +1 more source