Results 41 to 50 of about 18,102 (192)

Bacteria‐Derived 1‐Allylpiperazine Alleviates Symptoms of Parkinson's Disease Model by Promoting Autophagy

open access: yesAdvanced Science, EarlyView.
Parkinson's disease currently has no disease‐modifying therapies. In Caenorhabditis elegans, Escherichia coli E8 alleviates α‐synuclein‐provoked PD‐related defects through its bioactive metabolite 1‐ALPP, which combats PD by triggering AMPK/mTOR/HLH‐30‐dependent autophagy and suppressing α‐synuclein LLPS‐mediated fibrillization.
Mingqin Qu   +12 more
wiley   +1 more source

Immunomodulatory Effect of Tilapia (Oreochromis niloticus) Scale Gelatin Peptides in RAW264.7 Macrophages and Caenorhabditis elegans

open access: yesFood Safety and Health, EarlyView.
ABSTRACT Currently, small‐molecular‐weight collagen peptides are a research hotspot in functional factor development due to their high bioavailability and diverse bioactivities. In this study, gelatin was extracted from tilapia (Oreochromis niloticus) scales by hot water extraction, followed by pepsin hydrolysis and ultrafiltration to obtain the < 3 ...
Ya‐ru Liu   +5 more
wiley   +1 more source

The Influence of Phenol on the Growth, Morphology and Cell Division of Euglena gracilis

open access: yesLife, 2023
Phenol, a monocyclic aromatic hydrocarbon with various commercial uses, is a major pollutant in industrial wastewater. Euglena gracilis is a unicellular freshwater flagellate possessing secondary chloroplasts of green algal origin.
Alexandra Lukáčová   +6 more
doaj   +1 more source

Human biomarker navigator

open access: yesiMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li   +29 more
wiley   +1 more source

Salidroside mediated stabilization of Bcl -xL prevents mitophagy in CA3 hippocampal neurons during hypoxia

open access: yesNeurobiology of Disease, 2018
Chronic hypoxic stress results in deposition of lipofuscin granules in the CA3 region of hippocampal neurons which contributes to neurodegeneration and accelerated neuronal aging.
Suryanarayan Biswal   +6 more
doaj   +1 more source

Exposure–Recovery Approach for Hepatic Toxicity Analysis of Pyrethroid Lambda‐Cyhalothrin: Histopathological, Histochemical, and Biochemical Responses in Oreochromis niloticus

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Lambda‐cyhalothrin is a synthetic pyrethroid insecticide widely used in agriculture, but its potential to contaminate aquatic ecosystems and exert high toxicity on fish at low concentrations raises ecotoxicological concerns. While standard histopathological and biochemical assessments are common, the novel integration of pigment‐based ...
Carlos Eurico Fernandes   +7 more
wiley   +1 more source

Management Of Stargardt’s Disease Through Ayurvedic Science

open access: yesDelhi Journal of Ophthalmology, 2018
Stargardt’s disease is a hereditary disorder of the retina. There is a gradual loss of vision during childhood or adolescence and in a few cases, vision loss may be noticed in adulthood.
Santosh Kumar Shaw   +2 more
doaj   +1 more source

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider   +3 more
wiley   +1 more source

Anti-aging Effects and Mechanisms of Recombinant Human-derived Collagen on Aging Mouse Induced by D-Galactose

open access: yesShipin gongye ke-ji, 2023
In order to explore the anti-aging effect and mechanism of recombinant recombinant human-derived collagen (RHC), the aging mouse model was constructed through 300 mg/kg D-galactose intraperitoneal injection, and different doses of RHC were used to study ...
Jia LI   +5 more
doaj   +1 more source

Junctional sensitivity and atrophy progression rate of geographic atrophy secondary to age‐related macular degeneration

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To determine the relationship between the baseline junctional retinal sensitivity measured with microperimetry and the atrophy progression rate in eyes with geographic atrophy (GA) secondary to age‐related macular degeneration. Methods In this prospective cohort study, patients with GA were examined with fundus autofluorescence (FAF ...
Alexander Kai Thomsen   +5 more
wiley   +1 more source

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