STAR Protocols, 2023 Summary: The procedures used routinely for collagen and lipofuscin evaluation are, in many cases, qualitative, observer dependent, and disregard spatial distribution.
Laura García-Mendívil +4 more
doaj +1 more source
Resilience to Cardiac Aging in Greenland Shark Somniosus microcephalus [PDF]
Aging CellGreenland shark Somniosus microcephalus shows severe cardiac aging such as fibrosis, lipofuscin buildup, mitochondrial damage, and oxidative stress, unseen in comparison species Etmopterus spinax and Nothobranchius furzeri, yet remain healthy. S. microcephalus resilience suggests unique mechanisms that preserve heart function for centuries, offering ...
Chiavacci E +14 more
europepmc +2 more sources
Lipofuscin Hypothesis of Alzheimer’s Disease [PDF]
Dementia and Geriatric Cognitive Disorders Extra, 2011 The primary culprit responsible for Alzheimer’s disease (AD) remains unknown. Aβ protein has been identified as the main component of amyloid of senile plaques, the hallmark lesion of AD, but it is not definitively established whether the formation of extracellular Aβ deposits is the absolute harbinger of the series of pathological events that hit the ...
Giorgio Giaccone +3 more
openaire +3 more sources
Effect of season and behavioral activity on the hypopharyngeal glands of three honey bee Apis mellifera L. races under stressful climatic conditions of central Saudi Arabia [PDF]
Journal of Hymenoptera Research, 2019 Honey production gains are needed to deal with high demand in Saudi Arabia. The honey bee races are facing stressful hot-arid weather conditions that can affect different aspects of physiology and behavior.
Hussain Ali +5 more
doaj +3 more sources
Diagnostics, 2023 Age-related macular degeneration (AMD) may be associated with ABCA4 variants and is characterized by the accumulation of visual cycle-byproduct lipofuscin.
Hung-Da Chou +9 more
doaj +1 more source
In vitro and in vivo selection of potentially probiotic lactobacilli from Nocellara del Belice table olives [PDF]
, 2018 Table olives are increasingly recognized as a vehicle as well as a source of probiotic bacteria, especially those fermented with traditional procedures based on the activity of indigenous microbial consortia, originating from local environments.
Devirgiliis, C. +7 more
core +2 more sources
Retinal Pigment Epithelium Lipofuscin Proteomics [PDF]
Molecular & Cellular Proteomics, 2008 Lipofuscin accumulates with age in the retinal pigment epithelium (RPE) in discrete granular organelles and may contribute to age-related macular degeneration. Because previous studies suggest that lipofuscin contains protein that may impact pathogenic mechanisms, we pursued proteomics analysis of lipofuscin.
Kwok-Peng, Ng +14 more
openaire +2 more sources
The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease [PDF]
, 2015 Acknowledgements: Authors want to express their gratitude to Dr. P. Davies (Albert Einstein College of Medicine, Bronx, NY, USA) and Lester I. Binder (NorthWestern, Chicago, IL, USA) for the generous gift of mAbs (TG-3, Alz-50, and MC1), and (TauC-3 ...
Cárdenas-Aguayo, María C +10 more
core +2 more sources
Recent Advances and the Potential for Clinical Use of Autofluorescence Detection of Extra-Ophthalmic Tissues [PDF]
, 2020 The autofluorescence (AF) characteristics of endogenous fluorophores allow the label-free assessment and visualization of cells and tissues of the human body.
Aigner, Felix +7 more
core +1 more source
Autofluorescence in freshly isolated adult human liver sinusoidal cells
European Journal of Histochemistry, 2021 Autofluorescent granules of various sizes were observed in primary human liver endothelial cells (LSECs) upon laser irradiation using a wide range of wavelengths.
Anett Kristin Larsen +7 more
doaj +1 more source