Results 21 to 30 of about 17,675 (181)

Parity-Dependent Hemosiderin and Lipofuscin Accumulation in the Reproductively Aged Mouse Ovary

Analytical Cellular Pathology, 2018
The progressive decline of the ovarian follicle pool leads to reproductive ageing. The latter is accompanied by age-related disorders, including various types of cancer.
Ulises Urzua, Carlos Chacon, Renato Espinoza, Sebastián Martínez, Nicole Hernandez   +4 more
doaj   +1 more source

Lipofuscin Hypothesis of Alzheimer’s Disease [PDF]

Dementia and Geriatric Cognitive Disorders Extra, 2011
The primary culprit responsible for Alzheimer’s disease (AD) remains unknown. Aβ protein has been identified as the main component of amyloid of senile plaques, the hallmark lesion of AD, but it is not definitively established whether the formation of extracellular Aβ deposits is the absolute harbinger of the series of pathological events that hit the ...
Giorgio Giaccone, Laura Orsi, Chiara Cupidi, Fabrizio Tagliavini   +3 more
openaire   +3 more sources

A case report on lipofuscin deposition in a graft biopsy two years after kidney transplantation: an insignificant bystander or a pathogenic benefactor?

BMC Nephrology, 2019
Background Lipofuscin deposition is a characteristic manifestation of aging. There is very limited literature in humans and in animals describing these deposits in native kidneys.
Vivian W. Y. Leung, Sarah-Jeanne Pilon, Pierre O. Fiset, Shaifali Sandal   +3 more
doaj   +1 more source

LIPOFUSCIN ROLE IN INVOLUTIVE AND PATHOLOGICAL PROCESSES [PDF]

Саратовский научно-медицинский журнал, 2009
The modern data on the lipofuscin role in the processes of intracellular exchange have been analysed in the review. The ambiguity of the interpretation of lipofuscin accumulation according to its importance in involutive and pathological processes has ...
Maslyakova, A.A. Efimov
doaj  

Immunochemical detection of a lipofuscin-like fluorophore derived from malondialdehyde and lysine

Journal of Lipid Research, 2001
The accumulation of fluorescent age pigment or lipofuscin is a frequently observed age-associated cellular alteration in a variety of postmitotic cells of many species. These pigments are observed within granules composed, in part, of damaged protein and
Satoshi Yamada, Shigenori Kumazawa, Takeshi Ishii, Tsutomu Nakayama, Koichi Itakura, Noriyuki Shibata, Makio Kobayashi, Kensuke Sakai, Toshihiko Osawa, Koji Uchida   +9 more
doaj   +1 more source

Cannabinoid Receptor 2 Alters Social Memory and Microglial Activity in an Age-Dependent Manner

Molecules, 2021
Physiological brain aging is characterized by gradual, substantial changes in cognitive ability, accompanied by chronic activation of the neural immune system.
Joanna Agnieszka Komorowska-Müller, Tanushka Rana, Bolanle Fatimat Olabiyi, Andreas Zimmer, Anne-Caroline Schmöle   +4 more
doaj   +1 more source

Exacerbated Age-Related Hippocampal Alterations of Microglia Morphology, β-Amyloid and Lipofuscin Deposition and Presenilin Overexpression in Per1^−/−-Mice

Antioxidants, 2021
In humans, alterations of circadian rhythms and autophagy are linked to metabolic, cardiovascular and neurological dysfunction. Autophagy constitutes a specific form of cell recycling in many eukaryotic cells.
Jan Hendrik Börner, Oliver Rawashdeh, Abdelhaq Rami   +2 more
doaj   +1 more source

Salidroside mediated stabilization of Bcl -xL prevents mitophagy in CA3 hippocampal neurons during hypoxia

Neurobiology of Disease, 2018
Chronic hypoxic stress results in deposition of lipofuscin granules in the CA3 region of hippocampal neurons which contributes to neurodegeneration and accelerated neuronal aging.
Suryanarayan Biswal, Kalpana Kumari Barhwal, Debashree Das, Richa Dhingra, Nilima Dhingra, Tapas Chanda Nag, Sunil Kumar Hota   +6 more
doaj   +1 more source

Immunomodulatory Effect of Tilapia (Oreochromis niloticus) Scale Gelatin Peptides in RAW264.7 Macrophages and Caenorhabditis elegans

Food Safety and Health, EarlyView.
ABSTRACT Currently, small‐molecular‐weight collagen peptides are a research hotspot in functional factor development due to their high bioavailability and diverse bioactivities. In this study, gelatin was extracted from tilapia (Oreochromis niloticus) scales by hot water extraction, followed by pepsin hydrolysis and ultrafiltration to obtain the < 3 ...
Ya‐ru Liu, Xu Guo, Shu‐tao Sun, Rui‐rui Zhang, Chao Liu, Ning‐yang Li   +5 more
wiley   +1 more source

ACE‐inhibitory peptide Leu‐Tyr‐Ala in skeletal muscle actin exhibits anti‐aging effects through the inhibition of acn‐1 in Caenorhabditis elegans

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Inhibitors of angiotensin‐converting enzyme (ACE) are used in pharmaceuticals and functional foods. Captopril, a well‐known ACE inhibitor, extends the lifespan of the nematode Caenorhabditis elegans. Bioactive peptides derived from food sources are considered safe ACE inhibitors.
Issei Yokoyama, Minori Yamane, Kanaho Watanabe, Abdul Fatah, Yusuke Komiya, Jun Nagasao, Keizo Arihara   +6 more
wiley   +1 more source