Results 51 to 60 of about 17,764 (195)

Longevity and Growth of the Crabs Callinectes sapidus and Callinectes rathbunae (Decapoda: Portunidae) in Paraíso Tabasco Mexico

Acta Zoologica, EarlyView.
ABSTRACT Individual growth models are important in fisheries of natural populations and can be incorporated in production models to estimate their maximum sustainable yield. Blue crab species, Callinectes sapidus and Callinectes rathbunae were obtained in the Mecoacán lagoon, Paraíso, Tabasco Mexico by “nasa” and “yahual” nets. Biometric values such as
Candelario Jiménez‐Olivares, Sergio Cházaro‐Olvera, Fernando Álvarez‐Noguera, Mixtli Crisóstomo‐Pérez, Verónica Mitsui Saito‐Quezada, Isaías Hazarmabeth Salgado‐Ugarte   +5 more
wiley   +1 more source

A2E: A Component of Ocular Lipofuscin¶ [PDF]

Photochemistry and Photobiology, 2004
ABSTRACTThe presence of lipofuscin in post mitotic cells is considered a hallmark of the aging process. In the retinal pigment epithelium (RPE), lipofuscin is found as micrometer‐sized spherical particles and characterized by its yellow autofluorescence when exposed to blue light.
Laura E, Lamb, John D, Simon
openaire   +2 more sources

Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality

Medicina, 2020
Intra-lysosomal accumulation of the autofluorescent “residue” known as lipofuscin, which is found within postmitotic cells, remains controversial. Although it was considered a harmless hallmark of aging, its presence is detrimental as it continually ...
Ovidiu-Dumitru Ilie, Alin Ciobica, Sorin Riga, Nitasha Dhunna, Jack McKenna, Ioannis Mavroudis, Bogdan Doroftei, Adela-Magdalena Ciobanu, Dan Riga   +8 more
doaj   +1 more source

A novel myopathy with autophagic vacuoles associated with biallelic variants in CLN8

Brain Pathology, EarlyView.
We describe a novel adult‐onset myopathy with autophagic vacuoles and characteristic features of ceroid lipofuscinosis associated with biallelic CLN8 variants, seizures, and muscle weakness. Autophagosomal/lysosomal deposition of curvilinear, autofluorescent material containing the mitochondrial adenosine triphosphate (ATP) synthase membrane subunit c ...
Ulrika Lindgren, Carola Hedberg‐Oldfors, Kittichate Visuttijai, Sara Nordström, Hans Goebel, Anders Oldfors   +5 more
wiley   +1 more source

Artificial intelligence–based 3D segmentation of tangle‐associated TDP‐43 in neurodegeneration

Brain Pathology, EarlyView.
Multiplex immunostaining of anti‐phosphorylated TDP‐43, tau (AT8, pS396, TauC3, MN423, GT38), and Thioflavin S combined with AI‐based object recognition, reconstruction, and TAT maturation analysis pipeline in limbic regions revealed that distinct aggregation and tangle maturation patterns underscored region‐specific dynamics in the neurodegenerative ...
Gokhan Uruk, Hossam Youssef, Rodolfo G. Gatto, Nadia Hossain, Jennifer L. Whitwell, Robert R. Reichard, Keith A. Josephs   +6 more
wiley   +1 more source

β‐Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

EMBO Molecular Medicine, 2012
β‐Secretase (BACE1) is a major drug target for combating Alzheimer's disease (AD). Here we show that BACE1−/− mice develop significant retinal pathology including retinal thinning, apoptosis, reduced retinal vascular density and an increase in the age ...
Jun Cai, Xiaoping Qi, Norbert Kociok, Sergej Skosyrski, Alonso Emilio, Qing Ruan, Song Han, Li Liu, Zhijuan Chen, Catherine Bowes Rickman, Todd Golde, Maria B. Grant, Paul Saftig, Lutgarde Serneels, Bart de Strooper, Antonia M. Joussen, Michael E. Boulton   +16 more
doaj   +1 more source

Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley   +1 more source

Melanoma and Other Melanistic Lesions in Brown Bullhead Ameiurus nebulosus From Waterbodies in the Northeastern United States and Canada: Identification of Risk Factors

Journal of Fish Diseases, EarlyView.
ABSTRACT Melanistic lesions, including non‐raised black areas due to proliferations of melanocytes and melanomacrophages in the dermis and epidermis, as well as raised black areas consistent with melanoma, are described in brown bullhead (BBH) Ameiurus nebulosus from three water bodies in the northeastern United States and Quebec, Canada.
Vicki S. Blazer, Peter Emerson, Matthew Bodnar, Thomas Jones, David R. Russell, Matthew Pehrson, Cheyenne R. Smith, Danielle Cleveland, Mark J. Henderson, Patricia M. Mazik   +9 more
wiley   +1 more source

Ocular Manifestations of Infectious Salmon Anaemia Virus Infection in Atlantic Salmon (Salmo salar)

Journal of Fish Diseases, EarlyView.
ABSTRACT Eyes are essential sensory organs needed by teleost Atlantic salmon for high visual acuity and survival in both the wild and in aquaculture settings. In this work, we assessed the ocular manifestations of Infectious Salmon Anaemia Virus (ISAV) infection in Atlantic salmon by a cohabitation‐mediated infection assay and histological and ...
Emily Mahon, Rebecca R. Kwabiah, Hélène Paradis, Manuel A. Soto‐Dávila, Sathees Duglas, Raja Ram Gurung, Thurka Paramanathan, Ignacio Vasquez, Shams Al‐Badoosh, John Law, Javier Santander, Mark D. Fast, Robert L. Gendron   +12 more
wiley   +1 more source

An optimised protocol for the detection of lipofuscin, a versatile and quantifiable marker of cellular senescence.

PLoS ONE
Lipofuscin is a yellow-brown pigment typically found in the lysosomes that contains a mixture of molecules including lipids, metals and misfolded proteins.
Camilla S A Davan-Wetton, Trinidad Montero-Melendez   +1 more
doaj   +1 more source