Results 71 to 80 of about 17,675 (181)

Metformin attenuates cuprizone-induced mitochondrial dysfunction and senescence-associated changes in primary neuronal cells

Cell Structure and Function
Mitochondrial dysfunction and cellular senescence are key features of brain aging and neurodegenerative diseases. Cuprizone (CPZ), a mitochondrial toxin, induces oxidative stress, abnormal lipid metabolism, and iron accumulation in neurons and ...
Yeojin Kim, Hyunbum Jeon, Sun-Yeong Gwon, Sehyun Chae, Ji Young Mun   +4 more
doaj   +1 more source

Toward systemic lipofuscin removal

Rejuvenation Research
Lipofuscin is indigestible garbage that accumulates in the autophagic vesicles and cytosol of post-mitotic cells with age. Drs. Brunk and Terman postulated that lipofuscin accumulation is the main or at least a major driving factor in aging. They even posited that the evolution of memory is the reason why we get lipofuscin at all, as stable synaptic ...
openaire   +2 more sources

Resistance training does not increase myocellular garbage dumps: A pilot study on lipofuscin in skeletal muscle fibers of resistance trained young men

Physiological Reports
Lipofuscin (LF) is an intracellular aggregate associated with proteostatic impairments, especially prevalent in nondividing skeletal muscle fibers. Reactive oxygen species (ROS) drive LF‐formation. Resistance training (RT) improves muscle performance but
Daniel Jacko, Lukas Masur, Kirill Schaaf, Jonas Zacher, Käthe Bersiner, Markus deMarées, Wilhelm Bloch, Sebastian Gehlert   +7 more
doaj   +1 more source

Understanding RPE Lipofuscin [PDF]

Investigative Opthalmology & Visual Science, 2013
Janet R, Sparrow, John E, Dowling, Dean, Bok   +2 more
openaire   +2 more sources

Exogenous Iron Induces Mitochondrial Lipid Peroxidation, Lipofuscin Accumulation, and Ferroptosis in H9c2 Cardiomyocytes

Biomolecules
Lipid peroxidation plays an important role in various pathologies and aging, at least partially mediated by ferroptosis. The role of mitochondrial lipid peroxidation during ferroptosis remains poorly understood.
Konstantin G. Lyamzaev, He Huan, Alisa A. Panteleeva, Ruben A. Simonyan, Armine V. Avetisyan, Boris V. Chernyak   +5 more
doaj   +1 more source

Spotlight on fundus autofluorescence

Clinical Optometry, 2018
Ana M Calvo-Maroto,1 Alejandro Cerviño2 1Department of Ophthalmology, Clínica Universidad de Navarra, University of Navarra, Madrid, Spain; 2Optometry Research Group, Department of Optics and Optometry and Vision Sciences, University of ...
Calvo-Maroto AM, Cerviño A
doaj  

Understanding RPE Lipofuscin

Investigative Opthalmology & Visual Science, 2016
R Theodore, Smith, Sina, Farsiu, Michael, Allingham   +2 more
openaire   +2 more sources

Resilience to Cardiac Aging in Greenland Shark Somniosus microcephalus. [PDF]

Aging Cell
Chiavacci E, Steffensen KF, Delaroche P, Astoricchio E, Poulsen AB, Brayson D, Garibaldi F, Lanteri L, Pinali C, Valente GR, Vignati F, Steffensen JF, Shiels H, Tozzini ET, Cellerino A.   +14 more
europepmc   +1 more source

Multitargeted Modulation of Skin Dullness by HNHT Formulation: Synergistic Inhibition of Melanogenesis, Glycation, and Lipofuscin Deposition. [PDF]

J Cosmet Dermatol
Wang Z, Fan Y, Ling P.
europepmc   +1 more source

Exploring Polyene Construction Tactics for the Total Synthesis of Ocular Pyridinium Bisretinoids of Lipofuscin A2E and pdA2E. [PDF]

J Org Chem
Vidal B, Martínez C, Álvarez R, de Lera ÁR.   +3 more
europepmc   +1 more source