Results 71 to 80 of about 28,509 (234)
Anti-oxidative cellular protection effect of fasting-induced autophagy as a mechanism for hormesis [PDF]
, 2015 The aim of this investigation was to test the hypothesis that fasting-induced augmented lysosomal autophagic turnover of cellular proteins and organelles will reduce potentially harmful lipofuscin (age-pigment) formation in cells by more effectively ...
Ferrar Adams, DR +3 more
core +1 more source
International Medical Case Reports Journal, 2022 Alaa Fayed1,2 1Department of Ophthalmology, Kasr Al-Ainy School of Medicine, Cairo University, Giza, Egypt; 2Watany Research and Development Center, Watany Eye Hospital, Cairo, EgyptCorrespondence: Alaa Fayed, Department of Ophthalmology, Kasr Al-Ainy ...
Fayed A
doaj
Indian Journal of Ophthalmology, 2015 Purpose: To report the impact of transient, self-resolving, untreated "macular edema" detected on spectral domain optical coherence tomography in Asian Indian premature infants with retinopathy of prematurity (ROP) on visual acuity (VA) and refraction at
Anand Vinekar +9 more
doaj +1 more source
Medicina, 2020 Intra-lysosomal accumulation of the autofluorescent “residue” known as lipofuscin, which is found within postmitotic cells, remains controversial. Although it was considered a harmless hallmark of aging, its presence is detrimental as it continually ...
Ovidiu-Dumitru Ilie +8 more
doaj +1 more source
The Role of Oxidative Stress in Periodontitis
Journal of Periodontal Research, EarlyView.Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon +3 more
wiley +1 more source
Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis. [PDF]
, 2015 The degradation of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of the retinal pigment epithelium (RPE). Here, POS phagosomes were observed to associate with myosin-7a, and then kinesin-1, as
Diemer, Tanja +6 more
core +1 more source
Caenorhabditis elegans and probiotics interactions from a prolongevity perspective [PDF]
, 2019 Probiotics exert beneficial effects on host health through different mechanisms of action, such as production of antimicrobial substances, competition with pathogens, enhancement of host mucosal barrier integrity and immunomodulation.
Barbara Guantario +5 more
core +1 more source
Lipofuscin in human glaucomatous optic nerves [PDF]
Experimental Eye Research, 2013 Lipofuscin accumulation has been observed in a number of neurodegenerative diseases. We recently found that autofluorescent particles also occur in the aged human optic nerve. In this study we sought to determine the nature of these particles and their correlation with aging, age-related macular degeneration (AMD) and primary open angle glaucoma (POAG).
J P, Fernandez de Castro +5 more
openaire +2 more sources
Photochemistry and Photobiology, EarlyView.Gadusol‐rich extracts provide effective UVB protection and antioxidant activity in HaCaT cells and C. elegans, highlighting their potential as natural photochemoprotective agents for pharmaceutical and cosmetic applications. It also demonstrates remarkable in vitro antioxidant capacity and thermal stability over time.
Rocío Isla Naveira +9 more
wiley +1 more source
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway [PDF]
, 2012 Background Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear.
Emilie Giaime +8 more
core +4 more sources