Results 91 to 100 of about 28,509 (234)
PLoS ONELipofuscin is a yellow-brown pigment typically found in the lysosomes that contains a mixture of molecules including lipids, metals and misfolded proteins.
Camilla S A Davan-Wetton +1 more
doaj +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, Volume 16, Issue 5, Page 857-869, May 2026.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Successive Onset of Molecular, Cellular and Tissue-Specific Responses in Midgut Gland of Littorina littorea Exposed to Sub-Lethal Cadmium Concentrations [PDF]
, 2017 Cadmium (Cd) is one of the most harmful metals, being toxic to most animal species, including marine invertebrates. Among marine gastropods, the periwinkle (Littorina littorea) in particular can accumulate high amounts of Cd in its midgut gland.
Benito Fernández, Denis +4 more
core +3 more sources
Evaluation of ExPress glaucoma filtration device in Indian patients with advanced glaucoma
Indian Journal of Ophthalmology, 2015 ExPress glaucoma filtration device (GFD) has recently become available in India as a surgical option for glaucoma patients. We retrospectively evaluated the outcome of ExPress GFD in 12 eyes with advanced glaucoma with intraocular pressures (IOPs) not ...
Dewang Angmo +3 more
doaj +1 more source
Intercompartmental communication in senescence
FEBS Open Bio, Volume 16, Issue 5, Page 837-856, May 2026.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in [PDF]
, 2015 Catalpol is an effective component of rehmannia root and known to possess various pharmacological properties. The present study was aimed at investigating the potential effects of catalpol on the lifespan and stress tolerance using C.
Cha, Dong Seok +6 more
core +4 more sources
Indian Journal of Ophthalmology, 2015 Choroidal osteoma is a usually unilateral benign tumor of the choroid composed of mature bone. Optical coherence tomography (OCT) has been used to image osteoma for several years. With the advent of enhanced depth imaging (EDI) feature of spectral-domain
Rameez Hussain +3 more
doaj +1 more source
Cellular senescence: Molecular signatures and cellular remodeling
FEBS Open Bio, Volume 16, Issue 5, Page 818-820, May 2026.Cellular senescence, a state of stable cell‐cycle arrest accompanied by profound metabolic and secretory changes, has emerged as a central hallmark of aging and a key contributor to age‐associated diseases. Despite the great progress in understanding the characteristics, the underlying molecular mechanisms, and the role of senescent cells in several ...
Dimitris Kletsas
wiley +1 more source
Stargardt disease: clinical features, molecular genetics, animal models and therapeutic options [PDF]
, 2016 Stargardt disease (STGD1; MIM 248200) is the most prevalent inherited macular dystrophy and is associated with disease-causing sequence variants in the gene ABCA4 Significant advances have been made over the last 10 years in our understanding of both the
Fujinami, K +3 more
core +1 more source
Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1
Annals of Neurology, Volume 99, Issue 5, Page 1173-1178, May 2026.Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan +5 more
wiley +1 more source