Results 81 to 90 of about 28,509 (234)

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Mode of action of Cr(VI) in immunocytes of earthworms: Implications for animal health [PDF]

, 2017
Chromium (Cr) is one of the major and most detrimental pollutant, widely present in the environment as a result of several anthropogenic activities. In mammalian cells, Cr(VI) is known to enhance reactive oxygen species (ROS) production and to cause ...
Banni, M, Boeri, M, Moore, MN, Mou, Z, Sforzini, S, Viarengo, A   +5 more
core   +1 more source

β‐Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

EMBO Molecular Medicine, 2012
β‐Secretase (BACE1) is a major drug target for combating Alzheimer's disease (AD). Here we show that BACE1−/− mice develop significant retinal pathology including retinal thinning, apoptosis, reduced retinal vascular density and an increase in the age ...
Jun Cai, Xiaoping Qi, Norbert Kociok, Sergej Skosyrski, Alonso Emilio, Qing Ruan, Song Han, Li Liu, Zhijuan Chen, Catherine Bowes Rickman, Todd Golde, Maria B. Grant, Paul Saftig, Lutgarde Serneels, Bart de Strooper, Antonia M. Joussen, Michael E. Boulton   +16 more
doaj   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Demographic assessment of the blue crab (Callinectes sapidus) in Chesapeake Bay using extractable lipofuscins as age markers [PDF]

, 2003
The blue crab (Callinectes sapidus) plays an important economic and ecological role in estuaries and coastal habitats from the Gulf of Mexico to the east coast of North America, but demographic assessments are limited by length-based methods.
Harvey, H. Roger, Ju, Se-Jong, Secor, David H.   +2 more
core   +1 more source

Scoping studies to establish the capability and utility of a real-time bioaerosol sensor to characterise emissions from environmental sources [PDF]

, 2018
A novel dual excitation wavelength based bioaerosol sensor with multiple fluorescence bands called Spectral Intensity Bioaerosol Sensor (SIBS) has been assessed across five contrasting outdoor environments.
Alexis Attwood, Allan Bennett, Anderson, Bauer, Ben Williams, Borlée, Bünger, Catherine Rolph, Crawford, Crawford, Douglas, Enda Hayes, Frederic Coulon, Gabey, Gabey, Gabey, Gill Drew, Hallar, Hernandez, Hill, Huffman, Huffman, Huffman, Jahne, Kaye, Kerry Walsh, Li, Madsen, Mazar, Morris, O'Connor, O'Connor, O'Connor, Pan, Pan, Pankhurst, Pearce, Pearson, Perring, Pöhlker, Robert P. Kinnersley, Robinson, Roshchina, Saari, Samuel Collins, Schumacher, Sean Tyrrel, Shagun Khera, Sialve, Simon J.T. Pollard, Simon Jackson, Simon Parks, Sonia Garcia Alcega, Sun, Sykes, Taha, Taha, Taha, Toni Gladding, Toprak, van der Hoek, Vestlund, Walser, Wei, Yu, Zaheer Ahmad Nasir, Ziemba   +66 more
core   +6 more sources

Structural analysis of Cu/Zn‐superoxide dismutase linked to neurodegenerative disease by antibody‐guided cryo‐EM

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Accumulation of misfolded proteins is a hallmark of many neurodegenerative diseases. To characterize such misfolded species in vivo, conformation‐specific antibodies are widely used; however, limited knowledge of antibody–epitope interactions often hampers mechanistic insight.
Yuki Shino, Norifumi Muraki, Yui Kobatake, Hiroaki Kamishina, Hirofumi Kosuge, Makoto Nakakido, Kouhei Tsumoto, Yoshiaki Furukawa   +7 more
wiley   +1 more source

Effects of PAHs and dioxins on the earthworm Eisenia andrei: a multivariate approach for biomarker interpretation. [PDF]

, 2014
In this study, a battery of biomarkers was utilised to evaluate the stress syndrome induced in the earthworm Eisenia andrei by exposure to environmentally realistic concentrations of benzo[a]pyrene (B[a]P) and 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD)
Bencivenga, M, Boeri, M, Moore, MN, Sforzini, S, Viarengo, A   +4 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, Volume 16, Issue 5, Page 821-836, May 2026.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Multimodal fundus imaging in heredodystrophic and degenerative diseases of the retina [PDF]

, 2009
A tomografia de coerência óptica incorporou-se gradativamente ao contemporâneo arsenal diagnóstico em Oftalmologia, passando a exercer papel fundamental na investigação e condução de doenças oculares, particularmente na especialidade de Retina e Vítreo ...
CALUCCI, Daniela, COSTA, Rogério Alves, FERRARA, Daniela Cavalcanti, ORÉFICE, Juliana Lambert   +3 more
core   +2 more sources