Results 31 to 40 of about 501,516 (209)

The consistency and efficacy of optical coherence tomography for the evaluation of ocular torsion angle in children

Frontiers in Pediatrics
PurposeTo explore the consistency and efficacy of optical coherence tomography (OCT) for the evaluation of ocular torsion angle compared to fundus photography in children.MethodPatients who had undergone fundus photography and OCT within 1 day were ...
Rongjun Liu, Jingjing Zhao, Kaili Yu, Dehai Zhu   +3 more
doaj   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Diagnostic Accuracy of Hand-Held Fundus Camera and Artificial Intelligence in Diabetic Retinopathy Screening

Biomedicines, 2023
Our study aimed to assess the role of a hand-held fundus camera and artificial intelligence (AI)-based grading system in diabetic retinopathy (DR) screening and determine its diagnostic accuracy in detecting DR compared with clinical examination and a ...
Martina Tomić, Romano Vrabec, Đurđica Hendelja, Vilma Kolarić, Tomislav Bulum, Dario Rahelić   +5 more
doaj   +1 more source

CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. [PDF]

, 2009
Age-related macular degeneration (AMD) is a prevalent cause of blindness in Western societies. Variants in the genes encoding complement factor H (CFH), complement component 3 (C3) and age-related maculopathy susceptibility 2 (ARMS2) have repeatedly been
Weber, Bernhard H. F., Fleckenstein, Monika, Frank G Holz, Weber, B. H., Hendrik P N Scholl, Scholl, Hendrik P. N., Tim Becker, Ulrich Mansmann, Weinberger Andreas W. A., Schmitz-Valckenberg Steffen, Mackensen, F., Herold Christine, Holz, Frank G, Scholl Hendrik P. N., Weber, Bernhard H F, Andreas Mössner, Keilhauer, Claudia N, Scholl, Hendrik P N, Fritsche, Lars G., Steffen Schmitz-Valckenberg, Schmitz-Valckenberg, S., Claudia N Keilhauer, Weinberger, A. W., Fritsche, Lars G, Weinberger, Andreas W. A., Pauleikhoff, D., Becker, T., Andreas W A Weinberger, Adrion, Christine, Mansmann Ulrich, Weber Bernhard H. F., Becker Tim, Göbel, Arno, Mackensen Friederike, Holz, F. G., Monika Fleckenstein, Göbel, A., Adrion Christine, Holz Frank G., Scholl, H. P., Friederike Mackensen, Mackensen, Friederike, Mansmann, Ulrich, Göbel Arno, Becker, Tim, Fleckenstein Monika, Mössner, Andreas, Lars G Fritsche, Fritsche Lars G., Keilhauer Claudia N., Schmitz-Valckenberg, Steffen, Fritsche, L. G., Herold, Christine, Arno Göbel, Daniel Pauleikhoff, Weinberger, Andreas, Christine Herold, Mansmann, U., Christine Adrion, Bernhard H F Weber, Mössner, A., Pauleikhoff, Daniel, Keilhauer, C. N., Herold, C., Holz, Frank G., Adrion, C., Mößner Andreas, Pauleikhoff Daniel, Fleckenstein, M.   +68 more
core   +2 more sources

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Trainable COSFIRE filters for vessel delineation with application to retinal images [PDF]

, 2015
Retinal imaging provides a non-invasive opportunity for the diagnosis of several medical pathologies. The automatic segmentation of the vessel tree is an important pre-processing step which facilitates subsequent automatic processes that contribute to ...
Petkov, Nicolai, Azzopardi, George
core   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Automated retinal analysis [PDF]

, 2006
Diabetes is a chronic disease affecting over 2% of the population in the UK [1]. Long-term complications of diabetes can affect many different systems of the body including the retina of the eye.
Lowell, James ?, Lowell, James Α.
core  

Retinopathy online challenge: automatic detection of microaneurysms in digital color fundus photographs. [PDF]

, 2010
Contains fulltext : 89373.pdf (Publisher’s version ) (Open Access)The detection of microaneurysms in digital color fundus photographs is a critical first step in automated screening for diabetic retinopathy (DR), a common complication ...
Li, Q., Hiroshi Fujita, Karray, F., Mizutani, A, Hatanaka, Y, Abramoff, Michael D., Jane You, Roberto Hornero Member, Chisako Muramatsu, Quellec, G., Cochener, B, Cazuguel, G., Atsushi Mizutani, Hornero, R., Roux, Christian, van Ginneken, Bram, Cazuguel, Guy, You, Jane, Cochener, Beatrice, Quellec, Gwenole, Van Ginneken, B, Muramatsu, C., Lamard, M., Michael D. Abràmoff, Karray, Fakhri, Bob Zhang, Niemeijer, M., Fujita, H, Hatanaka, Y., Garc?a, M, Abramoff, M.D., Michael J. Cree Senior Member, Wu, X., S?nchez, CI, Roux, C., Quellec, G, Mizutani, A., Hatanaka, Yuji, Lamard, M, Hornero, Roberto, Niemeijer, M, Mayo, Augustin, Yuji Hatanaka, Christian Roux, Sanchez, Clara I., Hornero, R, You, J, Mayo, Agustin, Li, Qin, Zhang, Bob, Garcia, M., Fakhri Karray, Fujita, H., Cree, M.J., Lamard, Mathieu, Wu, Xiangqian, Zhang, B., García, María, Clara I. Sánchez Member, Sanchez, C.I., Fujita, Hiroshi, Niemeijer, Meindert, Guy Cazuguel Member, Meindert Niemeijer, Senior Member, Abr?moff, MD, Roux, C, Karray, F, Wu, Q, Mayo, A, Mathieu Lamard, Mayo, A., Mizutani, Atsushi, Bram Van Ginneken, Muramatsu, C, Muramatsu, Chisako, You, J., Cree, MJ, Cochener, B., Qin Li, Zhang, B, Xiangqian Wu, Student Member, Ginneken, B. van, Cazuguel, G, Cree, Michael J., Li, Q   +86 more
core   +2 more sources