Results 111 to 120 of about 774,438 (310)

Fungal Tremorgens

Journal of Food Protection, 1981
Contamination of feed supplies by fungal tremorgens has been well established. This fact, in conjunction with the widespread occurrence of fungi capable of producing tremorgenic metabolites, warrants further study to determine if these metabolites can contaminate our food supply.
openaire   +2 more sources

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Community and neighbourhood tree species richness effects on fungal species in leaf litter

, 2020
Investigating the effects of individual tree species on fungal species in leaf litter allows a mechanistic understanding of how tree diversity affects the diversity and composition of fungal species at the community level.
Liang, Yu, Bruelheide, Helge, Zhang, Naili, Wubet, Tesfaye, Trogisch, Stefan, Ma, Keping, Li, Yinong   +6 more
core   +1 more source

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source

Robots and Minimal, Physics‐Informed Features: A Hybrid Framework for Enzyme Catalysis

Advanced Science, EarlyView.
Robotic experimentation and physics‐informed machine learning combine to predict enzyme substrate scope. With a handful of interpretable features derived from docking and quantum mechanics calculations, our model rivals descriptor‐heavy AI approaches and extrapolates to unseen substrates and enzyme classes.
Natalia Onishchenko, Eric S. Larsen, Govind Paneru, Kisung Lee, Diana V. Kolygina, Yankai Jia, Elizabeth Maria Clarissa, Wai‐Shing Wong, Bartosz A. Grzybowski   +8 more
wiley   +1 more source

Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units : protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project [PDF]

, 2019
The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically ill adult patients in intensive care units (ICU).
Vazquez, J.A., Martin-Loeches, I., Garnacho-Montero, J, Rello, J., Timsit, JF, Muñoz, P, Arıkan Akdagli, S, Calandra, T., Alastruey-Izquierdo, A, Azoulay, E, Koehler, P, Vazquez, JA, De Waele, J.J., Arikan-Akdagli, S., Bassetti, M, Rebuffi, C, Dimopoulos, G., Cornely, O, Blot, Stijn, Poulakou, G, Hoenigl, M, Rebuffi, C., Lass-Flörl, C., Kullberg, BJ, Blot, S.I., de Lange, D.W., Koehler, P., Kullberg, B.J., De Waele, Jan, Grecchi, C, Grecchi, C., Azoulay, E., Zuccaro, V, Taccone, FS, Garnacho-Montero, J., Maertens, J, Torres, A, Alastruey-Izquierdo, A., Cuenca-Estrella, M, Hoenigl, M., Taccone, F.S., Righi, E., Muñoz, P., Kanj, SS, Scudeller, L, Poulakou, G., Kanj, S.S., Sanguinetti, M., De Rosa, FG, Akova, M., Torres, A., Martin-Loeches, I, Lamoth, F, De Rosa, F.G., Timsit, J.F., Sanguinetti, M, Lamoth, F., Maertens, J., Calandra, T, Cornely, O.A., Scudeller, L., Akova, M, Agvald-Ohman, C., Lass-Flörl, C, Zuccaro, V., Giacobbe, D.R., Dimopoulos, G, Agvald-Ohman, C, Righi, E, de Lange, DW, Giacobbe, DR, Rello, J, Bassetti, M., Cuenca-Estrella, M.   +73 more
core   +1 more source

Functional–Taxonomic Scaling Resolves Conflicting Average Genome Size Estimates Across Environmental Gradients

Advanced Science, EarlyView.
Based on genome size‐functional breadth theory, we introduce and validate a framework that adjudicates conflicting average genome size (AGS) estimates by testing which estimate yields a gap between scaled functional diversity and scaled taxonomic diversity that is consistent with the expected positive association between genome size and gene functional
Huanhuan Zhu, Xiaoye Chen, Qiushi Li, Chenyu Sun, Haihua Xia, Yingxin Huang, Cong Wang, Peilin Chen, Cheng Gao   +8 more
wiley   +1 more source

Preparation, Pharmaceutical Characterization, In-Vitro Release Kinetics, and Antifungal Efficacy Investigation of Fluconazole Niosomal Hydrogel [PDF]

Pharmaceutical Sciences
Background: Lipid vesicular systems can enhance the penetration of antifungal drugs like fluconazole in topical applications. Niosomes, composed of non-ionic surfactants and cholesterol, are a key type of lipid vesicles.
Mohammad Amin Raeisi Estabragh, Hossein Pardakhty, Abbas Pardakhty   +2 more
doaj   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source