Results 51 to 60 of about 1,370,542 (343)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Infections Mimicking Malignancy in Kano, Nigeria: A Teaching Hospital Experience

The Annals of African Surgery, 2022
Objective: This study aimed to evaluate the pattern of presentation of infectious lesions mimicking malignancy. This will serve to heighten clinical indices of suspicion and prevent unwarranted aggressive management. Methods: This is a 19-year (1999-2017)
Abdulrazaq Jimoh Ajanaku, Akinfenwa Atanda Taoheed, Usman Bello Mohammed, Muhammad Haruna Sanusi, Zubaida Adamu Gwaram   +4 more
doaj   +1 more source

Amphibian fungal panzootic causes catastrophic and ongoing loss of biodiversity

Science, 2019
The demise of amphibians? Rapid spread of disease is a hazard in our interconnected world. The chytrid fungus Batrachochytrium dendrobatidis was identified in amphibian populations about 20 years ago and has caused death and species extinction at a ...
B. Scheele, F. Pasmans, L. Skerratt, L. Berger, A. Martel, W. Beukema, A. Acevedo, P. Burrowes, Tamilie Carvalho, A. Catenazzi, I. J. De la Riva, M. Fisher, Sandra V. Flechas, C. Foster, Patricia Frías-Álvarez, T. Garner, B. Gratwicke, J. Guayasamin, Mareike Hirschfeld, J. Kolby, T. Kosch, E. La Marca, D. Lindenmayer, K. Lips, A. Longo, Raúl Maneyro, Cait A. McDonald, J. Mendelson, Pablo Palacios-Rodríguez, G. Parra-Olea, C. Richards‐Zawacki, Mark‐Oliver Rödel, Sean M. Rovito, C. Soto-Azat, L. F. Toledo, J. Voyles, C. Weldon, S. Whitfield, M. Wilkinson, K. Zamudio, S. Canessa   +40 more
semanticscholar   +1 more source

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

FEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui, Ariel Kushmaro, Hana Barak, Anja Poehlein, Rolf Daniel, Hans‐Jürgen Mägert   +5 more
wiley   +1 more source

Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes

Science, 2018
Defense cargo shuttles in vesicles Plants can use small RNAs (sRNAs) to interfere with virulence factor gene expression in pathogens. Cai et al. show that the small mustard plant Arabidopsis shuttles defensive sRNAs into the necrotrophic fungus Botrytis ...
Qiang Cai, Lulu Qiao, Ming Wang, Baoye He, F. Lin, Jared Palmquist, Sienna-Da Huang, Hailing Jin   +7 more
semanticscholar   +1 more source

Anti-Fungal Efficacy and Mechanisms of Flavonoids

Antibiotics, 2020
The prevalence of fungal infections is growing at an alarming pace and the pathogenesis is still not clearly understood. Recurrence of these fungal diseases is often due to their evolutionary avoidance of antifungal resistance.
Mohammed Saleh Al Aboody, Suresh Mickymaray   +1 more
semanticscholar   +1 more source

Interaction of class III cellobiose dehydrogenase with lytic polysaccharide monooxygenase

FEBS Open Bio, EarlyView.
The activity of lytic polysaccharide monooxygenase (LPMO) is supported by its auxiliary enzyme cellobiose dehydrogenase (CDH). The catalytic activity of both enzymes is coupled by electron transfer and a cyclic cascade generating substrates for both enzymes – hydrogen peroxide for LPMO and oxidized and non‐oxidized cellobiose and cello‐oligosaccharide ...
Angela Giorgianni, Florian Csarman, Peicheng Sun, Mirjam Kabel, Roland Ludwig   +4 more
wiley   +1 more source

Immunotherapy of invasive fungal infection in hematopoietic stem cell transplant recipients [PDF]

, 2013
Despite the availability of new antifungal compounds, invasive fungal infection remains a significant cause of morbidity and mortality in children and adults undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Allogeneic HSCT recipients
Klingebiel, Thomas, Lehrnbecher, Thomas, Schmidt, Stanislaw, Tramsen, Lars   +3 more
core   +2 more sources

A community-driven reconstruction of the Aspergillus niger metabolic network

Fungal Biology and Biotechnology, 2018
Background Aspergillus niger is an important fungus used in industrial applications for enzyme and acid production. To enable rational metabolic engineering of the species, available information can be collected and integrated in a genome-scale model to ...
Julian Brandl, Maria Victoria Aguilar-Pontes, Paul Schäpe, Anders Noerregaard, Mikko Arvas, Arthur F. J. Ram, Vera Meyer, Adrian Tsang, Ronald P. de Vries, Mikael R. Andersen   +9 more
doaj   +1 more source

Fungal microbiota dysbiosis in IBD

Gut, 2016
Objective The bacterial intestinal microbiota plays major roles in human physiology and IBDs. Although some data suggest a role of the fungal microbiota in IBD pathogenesis, the available data are scarce.
H. Sokol, V. Leducq, H. Aschard, H. Pham, Sarah Jégou, C. Landman, David Cohen, G. Liguori, A. Bourrier, I. Nion‐Larmurier, J. Cosnes, P. Seksik, P. Langella, D. Skurnik, Mathias L. Richard, L. Beaugerie   +15 more
semanticscholar   +1 more source