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Invasive fungal infections [PDF]
Clinical Medicine, 2013 #### Key points Invasive fungal infections are often rapidly life threatening and require prompt diagnosis and therapy as well as specialist consultation First-line agents for the treatment of invasive aspergillosis include voriconazole and liposomal amphotericin B Therapeutic drug ...
William, Hope +2 more
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Journal of Fungi, 2021 The precise characterization of the mechanisms modulating Aspergillus fumigatus survival within airway epithelial cells has been impaired by the lack of live-cell imaging technologies and user-friendly quantification approaches. Here we described the use
Nagwa Ben-Ghazzi +7 more
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Brain Pathology, 1997 Fungal infections have increased in frequency in the last decades because of the growing number of immunocompromised patients who survive longer periods of time than in the past, the widespread use of immunosuppressive drugs, a large aging population with increased numbers of malignancies, and the spread of AIDS.
L, Chimelli, M B, Mahler-Araujo
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The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus
Nature Communications, 2020 Resistance to primary treatments of invasive aspergillosis is growing. Here, the authors generate a knockout library for 484 transcription factors in Aspergillus fumigatus, and show that loss of the NCT complex leads to cross-resistance to all primary ...
Takanori Furukawa +22 more
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Lung colonization by Aspergillus fumigatus is controlled by ZNF77
Nature Communications, 2018 Aspergillus fumigatus regularly colonises the lungs but in the context of respiratory disease can be associated with increased pathology. Here the authors show mutations in ZNF77 result in altered bronchial epithelial characteristics and enhanced fungal ...
Sara Gago +6 more
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MycoKeys, 2018 During the course of a study on the functional biodiversity of the mycobiota inhabiting rainforests in Thailand, a fungal strain was isolated from a plant sample and shown to represent an undescribed species, as inferred from a combination of ...
Zeljka Rupcic +5 more
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Poorly controlled asthma – Easy wins and future prospects for addressing fungal allergy
Allergology International, 2023 Poorly controlled asthma is especially common in low resource countries. Aside from lack of access to, or poor technique with, inhaled beta-2 agonists and corticosteroids, the most problematic forms of asthma are frequently associated with both fungal ...
David W. Denning, Lorraine T. Pfavayi
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Estimated burden of fungal infections in Kenya
Journal of Infection in Developing Countries, 2016 Introduction: Kenya is a developing country with a high rate of tuberculosis (TB) and a moderate HIV infection burden. No estimate of the burden of fungal diseases in Kenya is published.
John Abuga Guto +2 more
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F1000ResearchBackground Pulmonary infections caused by Aspergillus fumigatus are a global health concern. In the lungs, A. fumigatus employs a variety of virulence and adaptation mechanisms that allows it to survive and evade local immune responses. A.
Kayleigh Earle +6 more
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