Results 1 to 10 of about 413,546 (332)

Hsp90 governs dispersion and drug resistance of fungal biofilms [PDF]

, 2011
Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
A Lupetti, A Viudes, C d'Enfert, CA Kumamoto, CJ Nobile, CJ Nobile, D Andes, D Shahinas, David Andes, E Mowat, EM Kojic, ET Burt, G Ramage, G Ramage, G Ramage, G Ramage, G Ramage, Gordon Ramage, J McCourtie, J Nett, J Trepel, JB Anderson, JC Young, JE Nett, Jeniel Nett, Jose L. Lopez-Ribot, JR Blankenship, JS Finkel, L Ostrosky-Zeichner, LE Cowen, LE Cowen, LE Cowen, LE Cowen, LE Cowen, Leah E. Cowen, LH Pearl, LS Wilson, M Taipale, MA Pfaller, MA Pfaller, MJ Seidler, ML Richard, MM McNeil, Nicole Robbins, P Perumal, P Uppuluri, P Uppuluri, P Uppuluri, P Uppuluri, P Uppuluri, PK Mukherjee, Priya Uppuluri, R Pallavi, Ranjith Rajendran, Robin Charles May, RS Shapiro, RS Shapiro, S Garcia-Sanchez, S Park, S Perea, SD Singh, SJ Lin, SL LaFayette, SM Noble, SV Balashov, SZ Usmani, TE Zaoutis, Y Kaneko, YS Kim, Z Odabasi   +69 more
core   +27 more sources

CYP51 Paralogue Structure Is Associated with Intrinsic Azole Resistance in Fungi

mBio, 2021
Azole antifungals are the main treatment for fungal disease in humans. Many species are intrinsically resistant to azoles—in other words all members of the species are resistant without prior exposure—and we do not understand why.
N. Van Rhijn, M. Bromley, M. Richardson, P. Bowyer   +3 more
doaj   +1 more source

Antagonism of the Azoles to Olorofim and Cross-Resistance Are Governed by Linked Transcriptional Networks in Aspergillus fumigatus

mBio, 2022
Aspergillosis, in its various manifestations, is a major cause of morbidity and mortality. Very few classes of antifungal drugs have been approved for clinical use to treat these diseases and resistance to the first-line therapeutic class, the triazoles ...
Norman van Rhijn, Sam Hemmings, Isabelle S. R. Storer, Clara Valero, Hajer Bin Shuraym, Gustavo H. Goldman, Fabio Gsaller, Jorge Amich, Michael J. Bromley   +8 more
doaj   +1 more source

Quantitative Monitoring of Mycelial Growth of Aspergillus fumigatus in Liquid Culture by Optical Density

Microbiology Spectrum, 2022
Filamentous fungi form multicellular hyphae, which generally form pellets in liquid shake cultures, during the vegetative growth stage. Because of these characteristics, growth-monitoring methods commonly used in bacteria and yeast have not been applied ...
Ken Miyazawa, Takashi Umeyama, Yasutaka Hoshino, Keietsu Abe, Yoshitsugu Miyazaki   +4 more
doaj   +1 more source

Voriconazole treatment of Candida tropicalis meningitis: persistence of (1,3)-b-D-glucan in the cerebrospinal fluid is a marker of clinical and microbiological failure [PDF]

, 2016
Introduction: Infections are still the most common complications of cerebral shunt procedures. Even though fungal etiologies are considered to be rare, they are associated with significant morbidity and mortality.
Brunetti, Grazia, Ceccarelli, Giancarlo, Fallani, Stefania, Ghezzi, Maria Cristina, Marsiglia, Carolina, Novelli, Andrea, Raponi, Giammarco, Venditti, Mario   +7 more
core   +13 more sources

The Consequences of Our Changing Environment on Life Threatening and Debilitating Fungal Diseases in Humans

Journal of Fungi, 2021
Human activities have significantly impacted the environment and are changing our climate in ways that will have major consequences for ourselves, and endanger animal, plant and microbial life on Earth.
Norman van Rhijn, Michael Bromley
doaj   +1 more source

Distinct Cohorts of Aspergillus fumigatus Transcription Factors Are Required for Epithelial Damage Occurring via Contact- or Soluble Effector-Mediated Mechanisms

Frontiers in Cellular and Infection Microbiology, 2022
Damage to the lung epithelium is a unifying feature of disease caused by the saprophytic fungus Aspergillus fumigatus. However, the mechanistic basis and the regulatory control of such damage is poorly characterized.
Sayema Rahman, Norman van Rhijn, Panagiotis Papastamoulis, Darren D. Thomson, Darren D. Thomson, Zorana Carter, Rachael Fortune-Grant, Magnus Rattray, Michael John Bromley, Elaine Bignell, Elaine Bignell   +10 more
doaj   +1 more source

Courtship Ritual of Male and Female Nuclei during Fertilization in Neurospora crassa

Microbiology Spectrum, 2021
Sexual reproduction is a key process influencing the evolution and adaptation of animals, plants, and many eukaryotic microorganisms, such as fungi.
Sylvain Brun, Hsiao-Che Kuo, Chris E. Jeffree, Darren D. Thomson, Nick Read   +4 more
doaj   +1 more source

Ca²⁺ Signalling Differentially Regulates Germ-Tube Formation and Cell Fusion in Fusarium oxysporum

Journal of Fungi, 2022
Fusarium oxysporum is an important plant pathogen and an emerging opportunistic human pathogen. Germination of conidial spores and their fusion via conidial anastomosis tubes (CATs) are significant events during colony establishment in culture and on ...
Smija M. Kurian, Alexander Lichius, Nick D. Read   +2 more
doaj   +1 more source

Pathogenicity and virulence of Aspergillus fumigatus

Virulence, 2023
Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major cause of morbidity and mortality globally. Compromised lung defences arising from immunosuppression, chronic respiratory conditions or more recently, concomitant viral or
Kayleigh Earle, Clara Valero, Daniel P. Conn, George Vere, Peter C. Cook, Michael J. Bromley, Paul Bowyer, Sara Gago   +7 more
doaj   +1 more source