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Invasive Fungal Infection [PDF]

Deutsches Ärzteblatt international, 2019
The incidence of invasive fungal infection is approximately 6 cases per 100 000 persons per year. It is estimated that only half of such infections are detected during the patient's lifetime, making this one of the more common overlooked causes of death in intensive-care patients.
Marie, von Lilienfeld-Toal, Johannes, Wagener, Hermann, Einsele, Oliver A, Cornely, Oliver, Kurzai   +4 more
openaire   +3 more sources

Vitamin C enhances corneal fungal infection treatment in mice via chemotaxis and anti-inflammation. [PDF]

Antimicrob Agents Chemother
Xie Y, Jian S, Yue J, Wang C, Dong J, He S, Liu S, Wang L, Zhang H.   +8 more
europepmc   +2 more sources

CYP51 Paralogue Structure Is Associated with Intrinsic Azole Resistance in Fungi

mBio, 2021
Azole antifungals are the main treatment for fungal disease in humans. Many species are intrinsically resistant to azoles—in other words all members of the species are resistant without prior exposure—and we do not understand why.
N. Van Rhijn, M. Bromley, M. Richardson, P. Bowyer   +3 more
doaj   +1 more source

Candida auris: An Overview of the Emerging Drug-Resistant Fungal Infection

Infection & Chemotherapy, 2022
Candida auris is an invasive fungal pathogen that has been recognized globally as a serious health threat due to its extensive innate and acquired resistance to antifungal drugs. A growing number of emerging cases of C.
A. Sanyaolu, C. Okorie, A. Marinkovic, A. Abbasi, S. Prakash, J. Mangat, Zaheeda Hosein, N. Haider, J. Chan   +8 more
semanticscholar   +1 more source

Antagonism of the Azoles to Olorofim and Cross-Resistance Are Governed by Linked Transcriptional Networks in Aspergillus fumigatus

mBio, 2022
Aspergillosis, in its various manifestations, is a major cause of morbidity and mortality. Very few classes of antifungal drugs have been approved for clinical use to treat these diseases and resistance to the first-line therapeutic class, the triazoles ...
Norman van Rhijn, Sam Hemmings, Isabelle S. R. Storer, Clara Valero, Hajer Bin Shuraym, Gustavo H. Goldman, Fabio Gsaller, Jorge Amich, Michael J. Bromley   +8 more
doaj   +1 more source

Quantitative Monitoring of Mycelial Growth of Aspergillus fumigatus in Liquid Culture by Optical Density

Microbiology Spectrum, 2022
Filamentous fungi form multicellular hyphae, which generally form pellets in liquid shake cultures, during the vegetative growth stage. Because of these characteristics, growth-monitoring methods commonly used in bacteria and yeast have not been applied ...
Ken Miyazawa, Takashi Umeyama, Yasutaka Hoshino, Keietsu Abe, Yoshitsugu Miyazaki   +4 more
doaj   +1 more source

Coronavirus Disease 2019–Associated Invasive Fungal Infection

Open Forum Infectious Diseases, 2021
Coronavirus disease 2019 (COVID-19) can become complicated by secondary invasive fungal infections (IFIs), stemming primarily from severe lung damage and immunologic deficits associated with the virus or immunomodulatory therapy.
J. Baddley, G. Thompson, S. Chen, P. White, Melissa D. Johnson, M. Nguyen, Ilan S. Schwartz, A. Spec, L. Ostrosky-Zeichner, Brendan R. Jackson, T. Patterson, P. Pappas   +11 more
semanticscholar   +1 more source

Overview of COVID-19-Associated Invasive Fungal Infection

Current Fungal Infection Reports, 2022
Invasive fungal infections are a complication of COVID-19 disease. This article reviews literature characterizing invasive fungal infections associated with COVID-19.
Akira A. Shishido, Minu Mathew, J. Baddley   +2 more
semanticscholar   +1 more source

Metagenomic Next-Generation Sequencing for Pulmonary Fungal Infection Diagnosis: Lung Biopsy versus Bronchoalveolar Lavage Fluid

Infection and Drug Resistance, 2021
Purpose Metagenomic next-generation sequencing (mNGS) is widely used for pulmonary infection; nonetheless, the experience from its clinical use in diagnosing pulmonary fungal infections is sparse. This study aimed to compare mNGS results from lung biopsy
Lei Yang, Junxiu Song, Yubao Wang, Jing Feng   +3 more
semanticscholar   +1 more source

Detrimental impact of the IL-33/ST2 axis in an animal infection model with Cryptococcus neoformans

Allergology International, 2023
Cryptococcus neoformans and Cryptococcus gattii are pathogenic fungi that infect the human respiratory system and cause life-threatening pulmonary cryptococcosis.
Keigo Ueno, Yoshitsugu Miyazaki
doaj   +1 more source