Results 121 to 130 of about 438,844 (285)

COVID-19 Therapeutics Use by Social Deprivation Index in England, July 2020–April 2023

COVID
Coronavirus disease-19 (COVID-19) has disproportionately affected certain demographics in England, exacerbating existing health disparities. Effective therapeutics are a critical line of defence against COVID-19, particularly for patients at elevated ...
Angela Falola, Hanna Squire, Sabine Bou-Antoun, Alessandra Løchen, Colin S. Brown, Alicia Demirjian   +5 more
doaj   +1 more source

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

Efficacy of TDF, TAF, TMF, and TDF-to-TAF switch in chronic hepatitis B: a network meta-analysis

BMC Gastroenterology
Objective We compared the efficacy of four treatment strategies for chronic hepatitis B (CHB): tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF), tenofovir amibufenamide (TMF), and TDF-to-TAF switch strategies strategy.
Shuqi Yang, Yijie Lin, Huatang Zhang, Yanlan Liang, Wenjin Yuan, Xing Wang, Wenwu Lin, Wencong Hong, Zhijun Su, Dawu Zeng, Xueping Yu   +10 more
doaj   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

Advanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao, Jiahe Su, Jiawei Yuan, Qinyan Cao, Yue Wu, Yuyang Xiao, Guang Yang, Ruomu Xia, Jingpeng Yang, Yanan Li, Lina Wu, He Huang, Lingtong Meng   +12 more
wiley   +1 more source

Clinical Characteristics and Prognosis of AIDS Complicated with Talaromycosis marneffei Infection: a Single-Center Retrospective Study

Infectious Diseases and Therapy
Introduction The objective of the study was to determine the clinical features and prognostic risk factors of acquired immunodeficiency syndrome (AIDS) combined with Talaromyces marneffei (TM) infection.
Zhangyan Weng, Yijie Lin, Wenliang Dai, Yijuan Zheng, Huatang Zhang, Minghui Zheng, Haoyi He, Youzhi Hong, Dawu Zeng, Zhijun Su, Xueping Yu   +10 more
doaj   +1 more source

Synergistic inhibition of pathogenic fungi by oleanolic acid combined with azoles

Microbiology Spectrum
Invasive fungal infections and emerging antifungal resistance mediated by pathogenic fungi, notably Candida spp., Aspergillus spp., Cryptococcus neoformans, and Exophiala dermatitidis, pose a critical challenge to global public health systems. This study
Tian Chen, Shaolan Liu, Fei Yang, Zhangxuan He, Menghua Tang, Lu Ge, Hongyi Zhang, Sijie Liu, Xiaolei Zhu, Mengqi Peng, Heng Zhang, Wenxu Cheng, Yi Sun   +12 more
doaj   +1 more source

Biofilm Inhibitory Abscisic Acid Derivatives from the Plant-Associated Dothideomycete Fungus, Roussoella sp.

Molecules, 2018
Roussoella species are well recorded from both monocotyledons and dicotyledons. As part of a research program to discover biologically active compounds from plant-associated Dothideomycetes in Thailand, the strain Roussoella sp.
Chayanard Phukhamsakda, Allan Patrick G. Macabeo, Kamila Tomoko Yuyama, Kevin David Hyde, Marc Stadler   +4 more
doaj   +1 more source

Pan2‐Pan3 Complex‐Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus

Advanced Science, EarlyView.
Discovery that deadenylation, rather than transcription, acts as the rate‐limiting step for developmental timing in a plant pathogen. Evidence that P‐body integrity and mRNA decay are mechanistically coupled to rapid cellular differentiation under environmental stress. Identification of Pan2‐Pan3 as a pathogen‐specific “meta‐virulence factor” absent in
Ziwei Lv, Junting Feng, Shenxian Zhou, Zhiguang Qu, Jun Peng, Xiao‐Lin Chen, Deng Chen   +6 more
wiley   +1 more source

CsdA‐LaeB Regulatory Hub Contributes to Aspergillus fumigatus Virulence via Fumiquinazoline C Biosynthesis

Advanced Science, EarlyView.
This study identifies a conserved CsdA‐LaeB hub in Aspergillus fumigatus that regulates secondary metabolite fumiquinazoline C (FqC). Disrupting this hub enhances FqC production and virulence, shedding new light on the post‐transcriptional regulatory logic linking secondary metabolism to pathogenicity and offering alternative strategies for diagnostic ...
Zili Song, Hongjiao Zhang, Leixin Ye, Yuxin Lei, Linqi Wang, Xiao Liu, Nayanna M. Mercado Soto, Nancy P. Keller, Berl R. Oakley, Can Zhao, Michael Bromley, Hongwei Liu, Lei Cai, Koon Ho Wong, Wen‐Bing Yin   +14 more
wiley   +1 more source