Results 141 to 150 of about 1,817,760 (259)
A Synthetic β‐Mannan Epitope Enables Immunization and Detection of Candida auris
Angewandte Chemie, EarlyView.A synthetic β‐mannan epitope enables both active and passive immunization against Candida auris. Conjugation to the carrier protein CRM197 induces protective antibody responses, while monoclonal antibodies targeting the same epitope support detection using a lateral flow assay, linking glycochemistry with antifungal prevention and diagnostics ...
Emelie E. Reuber +8 more
wiley +2 more sources
Introduction: Overview of Fungal Genomics
, 2018 Genome sequences and postgenomic tools have had a major impact on fungal research. When the first fungal genome sequences became available it became clear how much more complex fungal biology was than had been previously assumed. Since then an increasing
Tsang, Adrian +5 more
core +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background The modified endoscopic Denker's (MED) approach provides access to all maxillary sinus (MS) walls for resection of various MS and retromaxillary pathologies, but the anteromedial maxilla has historically been resected. This study determined complication rates and outcomes following MED with pyriform aperture (PA) preservation ...
Yasser Almansour +5 more
wiley +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear. Objective To identify gut microbiome‒plasma metabolomic signatures associated with GC responsiveness in CRSwNP patients and to compare their ...
Ying‐Ying Zhang +7 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.This study demonstrates that kojic acid–loaded nanostructured lipid carriers (KA‐NLC) provide significant neuroprotection in a male rat model of middle cerebral artery occlusion (MCAO)–induced stroke. Treatment with KA‐NLCs reduced cerebral edema, improved motor and coordination balance and neurological scores, and enhanced spatial and avoidance memory.
Mobina Gheibi +11 more
wiley +1 more source
, 2013 深在性真菌症を対象としたLiposomal amphotericin B（L-AMB）の多施設共同，非対照試験を実施した。対象は真菌感染症と確定診断された患者または真菌感染症が疑われる患者とし，L-AMBの1日1回点滴静脈内投与における有効性，安全性および薬物動態を検討した。投与量は初回を2.5 mg/kgとし，5.0 mg/kgへの増量または1.0 mg/kgへの減量を可能とした。投与症例88例のうち安全性評価対象は86例，有効性評価対象は66例であった。 全体の有効性（主要評価項目：総合効果 ...
浦部, 晶夫 +12 more
core
Communications BiologyThe human lung is confronted daily with thousands of microbial invaders reaching the lower respiratory tract. An efficient response by the resident type 1 and type 2 alveolar epithelial cells (AECs) and alveolar macrophages (AMs) cells during the early ...
Christoph Saffer +4 more
doaj +1 more source
Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential
Angewandte Chemie International Edition, EarlyView.Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber +4 more
wiley +1 more source
Investigations into the Characteristics of Historic Barley Varieties with Reference to Fungal Diseases and Physiology [PDF]
The aim of this study was to characterise modern and historic barley varieties for agronomic and growth characteristics and to assess their resistance to Fusarium and mildew diseases.
Muhammed, Amal Abbas
core +2 more sources
Journal of Applied Polymer Science, EarlyView.PLA and PCL ocular implants prepared by tape casting and electrospinning provide sustained dexamethasone release with distinct release profiles governed by polymer type and processing method. The relationship between polymer structure, degradation behavior, and drug release demonstrates the potential of these fabrication techniques for controlled ...
Renata Bochanoski +6 more
wiley +1 more source