Results 61 to 70 of about 1,817,760 (259)

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Secondary antifungal prophylaxis in allogeneic hematopoietic stem cell transplant recipients with invasive fungal infection [PDF]

, 2018
Introduction: Invasive fungal infection (IFI) is a major cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients.
Pepeler, Mehmet Sezgin and Yildiz, Seyma and Yegin, Zeynep Arzu and Ozkurt, Zubeyde Nur and Tunccan, Ozlem Guzel and Erbas, Gonca and Kokturk, Nurdan and Kalkanci, Ayse and Yildirim, Zeki
core   +2 more sources

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Homeostatic control of an iron repressor in a GI tract resident

eLife, 2023
The transition metal iron plays a crucial role in living cells. However, high levels of iron are potentially toxic through the production of reactive oxygen species (ROS), serving as a deterrent to the commensal fungus Candida albicans for colonization ...
Yuanyuan Wang, Yinhe Mao, Xiaoqing Chen, Xinhuang Huang, Zhongyi Jiang, Kaiyan Yang, Lixing Tian, Tong Jiang, Yun Zou, Xiaoyuan Ma, Chaoyue Xu, Zili Zhou, Xianwei Wu, Lei Pan, Huaping Liang, Lin Zhong, Changbin Chen   +16 more
doaj   +1 more source

Fungal Infections

Proceedings of the American Thoracic Society, 1992
Abstract Over the last decade, there have been changes in the epidemiology of fungal infections as well as dramatic improvements in the antifungal armamentarium. Candida species are an increasingly important cause of infection among patients in intensive care units.
openaire   +3 more sources

Management of fungal colonization and infection after living donor liver transplantation [PDF]

, 2010
Background/Aims: Control of infection is important in liver transplant patients under immunosuppressive conditions. In particular, invasive fungal infection is often fatal if diagnosis and therapy are delayed.
Takatsuki, Mitsuhisa, Hidaka, Masaaki, Yamanouchi, Kosho, Kamohara, Yukio, Hamasaki, Koji, Tajima, Yoshitsugu, Miyazaki, Kensuke, Kanematsu, Takashi, Eguchi, Susumu   +8 more
core  

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity

mBio, 2017
Secondary metabolites are key mediators of virulence for many pathogens. Aspergillus fumigatus produces a vast array of these bioactive molecules, the biosynthesis of which is catalyzed by nonribosomal peptide synthetases (NRPSs) or polyketide synthases (
Anna Johns, Daniel H. Scharf, Fabio Gsaller, Hella Schmidt, Thorsten Heinekamp, Maria Straßburger, Jason D. Oliver, Mike Birch, Nicola Beckmann, Katharine S. Dobb, Jane Gilsenan, Bharatkumar Rash, Elaine Bignell, Axel A. Brakhage, Michael J. Bromley   +14 more
doaj   +1 more source

Cell Wall Composition Heterogeneity between Single Cells in Aspergillus fumigatus Leads to Heterogeneous Behavior during Antifungal Treatment and Phagocytosis

mBio, 2020
Aspergillus fumigatus can cause a variety of lung diseases in immunocompromised patients, including life-threatening invasive aspergillosis. There are only three main classes of antifungal drugs currently used to treat aspergillosis, and antifungal ...
Robert-Jan Bleichrodt, Peter Foster, Gareth Howell, Jean-Paul Latgé, Nick D. Read   +4 more
doaj   +1 more source

Fungal infection strategies [PDF]

Virulence, 2019
Fungi are increasingly recognized as the cause of not only superficial infections, which affect many people but are relatively easy to treat, but also invasive and disseminated infections.
openaire   +3 more sources