Results 81 to 90 of about 295,984 (208)

Benzophenone Derivatives as a New Class of Anti‐Infectives Against Acanthamoeba spp

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
Analogues of the human oxidosqualene cyclase inhibitor Ro 48‐8071 were designed, synthesized, and tested against Acanthamoeba hatchetti, one of the pathogens causing Acanthamoeba keratitis. The N‐propargyl derivative 4f showed strong amoebicidal activity with complete eradication of trophozoites and cysts, while exhibiting low toxicity toward human ...
Tomas Rimkus, Hannes Geisler, Taha B. El‐Jourani, Aurélien F. A. Moumbock, Matthias Schiedel, Stephan Reichl   +5 more
wiley   +1 more source

Advancing Treatment of Degenerative Eye Diseases at the Nanoscale

Smart Medicine, Volume 5, Issue 4, August 2026.
Nanotherapeutics possess the potential to overcome longstanding bottlenecks in treating degenerative ophthalmic diseases. With a highly tunable surface chemistry, nanotechnology platforms can be customized to navigate specific anatomical barriers in the eye and target pathways of diseases.
Li Yao Jin, Evashiniee G. P. Selvam, Qinsong Mei, Chi D. Luu, Yeannie H. Y. Yap, Daniel B. L. Teh   +5 more
wiley   +1 more source

Management of fungal keratitis: Topical or Systemic therapy?

Vision Pan-America, 2014
Currently, there are no level one evidence-based studies comparing systemic vs topical therapy for the management of fungal keratitis. Information on systemic efficacy alone or in combination with topical use is rare.
Darlene Miller, Eduardo C. Alfonso
doaj   +1 more source

Microenvironment‐Responsive Drug Delivery Systems for Ocular Surface Diseases: Mechanisms, Applications, and Translational Challenges

Small Science, Volume 6, Issue 8, August 2026.
Microenvironment‐responsive drug delivery systems overcome ocular physiological barriers by responding to temperature, pH, ions, reactive oxygen species, and enzymes. This review bridges material design, performance evaluation, and clinical translation, offering actionable insights for treating dry eye disease, infectious keratitis, and corneal ...
Jiamin Liu, Liangbo Chen, Yao Fu, Siyi Zhang   +3 more
wiley   +1 more source

Clinical experiences in fungal keratitis caused by Acremonium

, 2014
Seong-Jae Kim,1,2 Yong-Wun Cho,1 Seong-Wook Seo,1,2 Sun-Joo Kim,2,3 Ji-Myong Yoo1,21Department of Ophthalmology, 2Gyeongsang Institute of Health Science, 3Department of Laboratory Medicine, Gyeongsang National University, College of Medicine, Jinju ...
Seo SW, Yoo JM, Cho YW, Kim SJ
core  

Dual‐Targeting, Hybrid Antifungal Agents Targeting Candida albicans—An Overview

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
The selective, single‐targeting antifungal agents serve as the parent molecule(s) for the design of dual‐targeting, hybrid fungicidal agents and are discussed and compared, which enables the researchers to understand the logic for designing multi‐targeting new chemical entities (NCEs) that can exhibit dual‐sword attack on Candida albicans. ABSTRACT Due
Sarmistha Pal, Sriparna Pusti, Iftakhar Hussain Ansari, Sanchita Pradhan, Hritabrata Bhattacharya, Shuvradip Das   +5 more
wiley   +1 more source

Pharmacotherapy of Fungal Keratitis [PDF]

, 2018
The article presents a review of the literature on the various possibilities in application of antifungal drugs in the treatment of fungal keratitis. The fungal infection of the eye is one of the problems unsolved in the modern ophthalmology, which often
K. I. Belskaia, A. S. Obrubov
core   +1 more source

Recent advances in diagnosis and management of Mycotic Keratitis

Indian Journal of Ophthalmology, 2016
Mycotic keratitis is a major cause of corneal blindness, especially in tropical and subtropical countries. The prognosis is markedly worse compared to bacterial keratitis.
Prafulla K Maharana, Namrata Sharma, Ritu Nagpal, Vishal Jhanji, Sujata Das, Rasik B Vajpayee   +5 more
doaj   +1 more source

Ring infiltrates in Pythium keratitis

Oman Journal of Ophthalmology
This study highlights the clinical presentation of ring infiltrates (RI) in Pythium keratitis, typically associated with fungal or Acanthamoeba keratitis, emphasizing diagnostic and therapeutic challenges.
Amanjot Kaur, Amrita Mohanty, Sujata Das, Smruti Rekha Priyadarshini, Srikant Kumar Sahu   +4 more
doaj   +1 more source

Fungal keratitis in Lattice dystrophy

Indian Journal of Ophthalmology, 2010
We report a case of fungal keratitis occurring in a patient with lattice dystrophy. A 57-year-old farmer presented with a corneal ulcer following probable entry of paddy husk in the right eye, of one month duration. Corneal scraping revealed pigmented fungal filaments while culture grew Alternaria alternata. Treatment with 5% natamycin eye drops and 1%
Chatterjee Samrat, Agrawal Deepshikha
openaire   +3 more sources