Results 111 to 120 of about 327,997 (299)

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Earthworms Significantly Alter the Composition, Diversity, Abundance and Pathogen Load of Fungal Communities in Sewage Sludge from Different Urban Wastewater Treatment Plants

Pathogens
Management of sewage sludge is of ongoing concern because this waste product is generated continuously and contains high levels of harmful constituents. Among these constituents, fungal pathogens are of increasing concern.
Manuel Aira, Ana Gómez-Roel, Jorge Domínguez   +2 more
doaj   +1 more source

Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits

Advanced Science, EarlyView.
Yeast microbes in fermenting fruits attract both host flies and their parasitoid wasps. Female Leptopilina boulardi detect yeast‐emitted ethyl esters via two olfactory receptors, LbouOR167 and LbouOR136. A conserved residue, Leu159, is critical for binding these compounds, enabling female wasps to locate host‐rich habitats.
Yueqi Lu, Lan Pang, Wenqi Shi, Ting Feng, Zhi Dong, Yifeng Sheng, Sicong Zhou, Longtao Yu, Hao Guo, Ying Wang, Jiani Chen, Jianhua Huang   +11 more
wiley   +1 more source

Fungal pathogens exposed

, 2023
Fungal pathogens are on the rise. Annually more than one billion people are affected by superficial, allergic and mucosal fungal infections. However, of highest concern are the life-threatening invasive fungal infections. An increasing at-risk population together with inaccurate diagnostics and limited treatment options led to a dramatic increase in ...
openaire   +2 more sources

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, EarlyView.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

Challenges and Strategies for Proteome Analysis of the Interaction of Human Pathogenic Fungi with Host Immune Cells

Proteomes, 2015
Opportunistic human pathogenic fungi including the saprotrophic mold Aspergillus fumigatus and the human commensal Candida albicans can cause severe fungal infections in immunocompromised or critically ill patients.
Thomas Krüger, Ting Luo, Hella Schmidt, Iordana Shopova, Olaf Kniemeyer   +4 more
doaj   +1 more source

Repression of the auxin response pathway increases Arabidopsis susceptibility to necrotrophic fungi

, 2008
In plants, resistance to necrotrophic pathogens depends on the interplay between different hormone systems, such as those regulated by salicylic acid (SA), jasmonic acid (JA), ethylene, and abscisic acid.
AbuQamar, Adie, Audenaert, Austin, Azevedo, Azevedo, Berrocal-Lobo, Berrocal-Lobo, Cao, Catlett, Chisholm, de Torres-Zabala, del Pozo, Devoto, Dharmasiri, Dharmasiri, Dubacq, El Oirdi, Ferrari, Ferry, Feys, Geldner, Glazebrook, Glickmann, Govrin, Gray, Gray, Gray, Hagen, Hellmann, Hernández-Blanco, Holt, Holt, Kepinski, Laurie-Berry, Leyser, Lincoln, Liu, Llorente, Lorenzo, Manulis, Maor, Marchant, Mauch-Mani, Muskett, Muskett, Nagpal, Nakashita, Navarro, Noël, Nürnberger, Paponov, Pickett, Quint, Ramos, Robert-Seilaniantz, Ruegger, Shirasu, Thomma, Thomma, Tiryaki, Tornero, Truman, Vandeputte, Wang, Woodward   +65 more
core   +1 more source

Pathogenic Roles for Fungal Melanins [PDF]

Clinical Microbiology Reviews, 2000
SUMMARYMelanins represent virulence factors for several pathogenic fungi; the number of examples is growing. Thus, albino mutants of several genera (in one case, mutated precisely in the melanizing enzyme) exhibit decreased virulence in mice. We consider the phenomenon in relation to known chemical properties of melanin, beginning with biosynthesis ...
openaire   +2 more sources

A Virus‐Inducible E3–RLCK–MADS Module Coordinates Suppression of Plant Immunity and Fertility in Rice

Advanced Science, EarlyView.
ABSTRACT Viruses often hijack host developmental programs to promote infection, but the mechanistic links between reproductive regulation and antiviral immunity remain incompletely understood. Here, we identify a virus‐triggered hierarchical degradation cascade that links antiviral immunity and fertility regulation in rice. We show that the rice grassy
Yuansheng Wu, Fengling Wu, Shiting Huang, Denglu Yang, Xin Lei, Xue Zhang, Na Liu, Peng Gan, Chuan Li, Jie Zhang, Ming Wu, Qingxiao Jia, Shanshan Zhao, Jianguo Wu   +13 more
wiley   +1 more source

Epidemiology and risk factors of fungal pathogens in sepsis: a prospective nationwide multicenter cohort study

BMC Infectious Diseases
Background The incidence of sepsis with identified fungal pathogens is increasing and is associated with higher morbidity and mortality. Co-infection with fungal infections in COVID-19 patients is attracting clinical attention.
Jeong Eun Lee, Da Hyun Kang, Hyekyeong Ju, Dong Kyu Oh, Su Yeon Lee, Mi Hyeon Park, Chae-Man Lim, Song I Lee, On behalf of the Korean sepsis Alliance (KSA) investigators   +8 more
doaj   +1 more source