Results 1 to 10 of about 374,732 (162)

Beyond the WHO classification of meningioma: using molecular diagnostics to guide management

Advances in Clinical Neuroscience & Rehabilitation, 2023
Meningioma are the most common primary brain tumour. Classically, meningioma are phenotypically grouped using the World Health Organisation (WHO) classification system.
Abigail Clynch, George E Richardson, Mohammad A Mustafa, Conor S Gillespie, Nitika Rathi, Ali Bakhsh, Rasheed Zakaria, Abdurrahman I Islim, Christopher P Millward, Michael D Jenkinson   +9 more
doaj   +1 more source

Molecular Diagnostics [PDF]

Journal of the American Academy of Orthopaedic Surgeons, 2015
Orthopaedic infections are complex conditions that require immediate diagnosis and accurate identification of the causative organisms to facilitate appropriate management. Conventional methodologies for diagnosis of these infections sometimes lack accuracy or sufficient rapidity. Molecular diagnostics is an emerging area of bench-to-bedside research in
Hyonmin, Choe, Carl A, Deirmengian, Noreen J, Hickok, Tiffany N, Morrison, Rocky S, Tuan   +4 more
openaire   +3 more sources

Clinical significance of HRAS and KRAS genes expression in patients with non–small-cell lung cancer - preliminary findings

BMC Cancer, 2021
Background The RAS family protooncogenes, including KRAS, NRAS and HRAS, encode proteins responsible for the regulation of growth, differentiation and survival of many cell types.
Milena Pązik, Katarzyna Michalska, Marta Żebrowska-Nawrocka, Izabela Zawadzka, Mariusz Łochowski, Ewa Balcerczak   +5 more
doaj   +1 more source

Detection of BRAF V600E in Fine-Needle Aspiration Samples of Thyroid Nodules by Droplet Digital PCR

International Journal of Endocrinology, 2022
Background. BRAF exon 15 p.V600E (BRAF V600E) mutation has been established as an important molecular marker for papillary thyroid carcinoma diagnosis by ultrasound-guided fine-needle aspiration biopsy (FNAB).
Sang-Yu Lu, Ying-Chao Chen, Jia-Lin Feng, Qin-Yi Zhou, Jing Chen, Chen-Fang Zhu, Miao-Miao Guo, Man-Man Zhang, Qian-Yue Zhang, Meng Lu, Liu Yang, Jing Wu, Shuang-Xia Zhao, Huai-Dong Song, Xiao-Ping Ye   +14 more
doaj   +1 more source

Assessment of the TGFB1 gene expression and methylation status of the promoter region in patients with colorectal cancer

Scientific Reports, 2022
The aim of this study was to evaluate the expression of the TGFB1 gene encoding the TGF-β1 cytokine in 64 patients, and then to compare it with clinico-pathological features.
Damian Wodziński, Agnieszka Wosiak, Jacek Pietrzak, Rafał Świechowski, Radzisław Kordek, Ewa Balcerczak   +5 more
doaj   +1 more source

Differential Expression of AP-2 Transcription Factors Family in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma—A Bioinformatics Study

Cells, 2023
Members of the activator protein 2 (AP-2) transcription factor (TF) family are known to play a role in both physiological processes and cancer development. The family comprises five DNA-binding proteins encoded by the TFAP2A to TFAP2E genes.
Dagmara Szmajda-Krygier, Adrian Krygier, Marta Żebrowska-Nawrocka, Jacek Pietrzak, Rafał Świechowski, Agnieszka Wosiak, Agnieszka Jeleń, Ewa Balcerczak   +7 more
doaj   +1 more source

Molecular diagnostic techniques [PDF]

Medicine, 2009
Clinical microbiology laboratories increasingly rely on molecular diagnostic techniques. The various formats of nucleic acid amplification are the most frequently used molecular tests in the diagnosis of infectious diseases. In many clinical settings, polymerase chain reaction (PCR) is clearly the method of choice due to its exquisite sensitivity and ...
Kurkela, Satu, Brown, David W.G.
openaire   +2 more sources

Molecular Pathogenesis of Fibrosis, Thrombosis and Surfactant Dysfunction in the Lungs of Severe COVID-19 Patients

Biomolecules, 2022
The global scope and scale of the SARS-CoV-2 pandemic led to huge amounts of important data from clinical observations and experimental analyses being collected, in particular, regarding the long-term impact of COVID-19 on lung tissue. Visible changes in
Adrian Krygier, Dagmara Szmajda-Krygier, Rafał Świechowski, Jacek Pietrzak, Agnieszka Wosiak, Damian Wodziński, Ewa Balcerczak   +6 more
doaj   +1 more source

Bioinformatics-Based Characterization of ATP-Binding Cassette Subfamily B Member 1 (ABCB1) Gene Expression in Non-Small-Cell Lung Cancer (NSCLC)

Applied Sciences, 2023
P-glycoprotein (P-gp) has been implicated in lung cancer development, disease progression, and patient survival. Changes in the ABCB1 expression level may correlate with tumorigenesis and the formation of multidrug resistance (MDR).
Agnieszka Maria Jeleń, Bartłomiej Strehl, Dagmara Szmajda-Krygier, Milena Pązik, Ewa Balcerczak   +4 more
doaj   +1 more source

miRNA in Molecular Diagnostics

Bioengineering, 2022
MicroRNAs are a class of small non-coding RNA molecules that regulate gene expression on post-transcriptional level. Their biogenesis consists of a complex series of sequential processes, and they regulate expression of many genes involved in all cellular processes. Their function is essential for maintaining the homeostasis of a single cell; therefore,
Maja Matulić, Paula Gršković, Andreja Petrović, Valerija Begić, Suzana Harabajsa, Petra Korać   +5 more
openaire   +3 more sources