Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A
Angewandte Chemie, EarlyView.Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham +11 more
wiley +2 more sources
Fungal Proteins from Sargassum spp. Using Solid-State Fermentation as a Green Bioprocess Strategy. [PDF]
Molecules, 2022 Bonilla Loaiza AM +8 more
europepmc +1 more source
Fungal Diversity and Cellulytic Activity in the Historic Huts, Ross Island, Antarctica
, 2007 The goal of this study was to undertake a microbial investigation of the Historic Huts areas on Ross Island, to gain knowledge of the fungal biodiversity and biochemical framework, focusing on the wood degrading potential of these fungi at both ...
Duncan, Shona Margaret
core
PHI-Nets: A Network Resource for Ascomycete Fungal Pathogens to Annotate and Identify Putative Virulence Interacting Proteins and siRNA Targets [PDF]
, 2019 Interactions between proteins underlie all aspects of complex biological mechanisms. Therefore, methodologies based on complex network analyses can facilitate identification of promising candidate genes involved in phenotypes of interest and put this ...
Lysenko, A. +11 more
core +1 more source
The antitumor activity of hydrophobin SC3, a fungal protein
Applied Microbiology and Biotechnology, 2012 The use of mushroom extracts has been common practice in traditional medicine for centuries, including the treatment of cancer. Proteins called hydrophobins are very abundant in mushrooms. Here, it was examined whether they have antitumor activity. Hydrophobin SC3 of Schizophyllum commune was injected daily intraperitoneally starting 1 day after tumor ...
Akanbi, M.H. +8 more
openaire +4 more sources
From Defense Executor to Engineering Target: Harnessing Lignin for Crop Resistance
Advanced Science, EarlyView.Lignin serves as both a physical and chemical executor of broad‐spectrum plant immunity. This review systematically summarizes classical and recent advances in lignin‐mediated immunity, outlines the multifaceted regulatory modules controlling lignification under biotic stress, discusses key physiological and biochemical mechanisms behind lignin‐based ...
Yanwen Yu +6 more
wiley +1 more source
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, EarlyView.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
Fungal hydrogenosomes contain mitochondrial heat-shock proteins
, 2003 At least three groups of anaerobic eukaryotes lack mitochondria and instead contain hydrogenosomes, peculiar organelles that make energy and excrete hydrogen.
Horner, David S +15 more
core +1 more source
Production of therapeutic proteins in fungal hosts [PDF]
Expert Opinion on Biological Therapy, 2004 Nicole, Ballew, Tillman, Gerngross
openaire +2 more sources
Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity
Advanced Science, EarlyView.Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai +7 more
wiley +1 more source