Results 91 to 100 of about 645,266 (318)

Fungal virulence genes as targets for antifungal chemotherapy [PDF]

Antimicrobial Agents and Chemotherapy, 1996
Fungal virulence genes have now met the age of molecular pathogenesis. The definition of virulence genes needs to be broad so that it encompasses the focus on molecular antifungal targets and vaccine epitopes. However, in the broad but simple definition of a virulence gene, there will be many complex genetic and host interactions which investigators ...
openaire   +2 more sources

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

A transcription factor-mediated regulatory network controls fungal pathogen colonization of insect body cavities

mBio
Successful host tissue colonization is crucial for fungal pathogens to cause mycosis and complete the infection cycle, in which fungal cells undergo a series of morphological transition-included cellular events to combat with hosts.
Juan Deng, Shuaishuai Huang, Yanze Kan, Yue Song, Xin Zhao, Ning Li, Xuewen Yao, Zhibing Luo, Yongjun Zhang   +8 more
doaj   +1 more source

An evolutionary perspective on zinc uptake by human fungal pathogens [PDF]

, 2015
DW is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 102549/Z/13/Z).Peer reviewedPublisher ...
Wilson, Duncan
core   +1 more source

A glycine-rich protein MoGrp1 functions as a novel splicing factor to regulate fungal virulence and growth in Magnaporthe oryzae

Phytopathology Research, 2019
Glycine-rich proteins (GRPs) have diverse amino acid sequences and are involved in a variety of biological processes. The role of GRPs in plant pathogenic fungi has not been reported.
Xusheng Gao, Changfa Yin, Xinsen Liu, Junbo Peng, Deng Chen, D. He, Wei Shi, Wensheng Zhao, Jun Yang, You-Liang Peng   +9 more
semanticscholar   +1 more source

Structural and Functional Characterization of EXPO‐Derived Extracellular Vesicles in Plants

Advanced Science, EarlyView.
In this study, 3D electron tomography (ET), cryo‐ET, and immunogold transmission electron microscopy (TEM) are employed to characterize plant extracellular vesicles (EVs) under physiological conditions. EVs are classified into three distinct categories according to their size, content, and molecular‐marker profiles. Furthermore, Exo70E2‐positive medium
Jiayang Gao, Yanbin Li, Shengqi Zhang, Yilin He, Zhiqi Liu, Juan Wang, Jingmin Hua, Jinyu Chen, Junru Zhong, Huan Zhong, Yiji Xia, Yong Cui, Liwen Jiang   +12 more
wiley   +1 more source

The antifungal mechanism of EntV-derived peptides is associated with a reduction in extracellular vesicle release.

PLoS Pathogens
Candida albicans, an opportunistic fungal pathogen, causes systemic and superficial infections, especially in immunocompromised patients. Treatment of fungal infections is complicated by limited antifungal options and the development of drug resistance ...
Giuseppe Buda De Cesare, Melissa R Cruz, Shane A Cristy, Luis A Vega, Robert Zarnowski, Antonino Zito, Shantanu Guha, David R Andes, Danielle A Garsin, Michael C Lorenz   +9 more
doaj   +1 more source

Conserved cAMP signaling cascades regulate fungal development and virulence [PDF]

FEMS Microbiology Reviews, 2001
Two well characterized signal transduction cascades regulating fungal development and virulence are the MAP kinase and cAMP signaling cascades. Here we review the current state of knowledge on cAMP signaling cascades in fungi. While the processes regulated by cAMP signaling in fungi are as diverse as the fungi themselves, the components involved in ...
C A, D'Souza, J, Heitman
openaire   +2 more sources

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Molecular and proteomic analyses highlight the importance of ubiquitination for the stress resistance, metabolic adaptation, morphogenetic regulation and virulence of Candida albicans [PDF]

, 2011
Peer reviewedPublisher ...
Alonso-Monge, Amerik, Andaluz, Bachmair, Brown, Brown, Brown, Calderone, Care, Cash, Chauhan, Cheng, Ciechanover, Ciechanover, Ciechanover, Dennison, Enjalbert, Enjalbert, Ernst, Finley, Finley, Fradin, Fraser, Friant, Garcia-Sanchez, Gietz, Glotzer, Gow, Hauser, Hershko, Hochstrasser, Hromatka, Hube, Hwang, Hwang, Jentsch, Jentsch, Johnson, Kaiser, Kim, Kolkman, Kunze, Leberer, Leng, Liu, Lo, Lorenz, Lorenz, MacCallum, MacCallum, Madura, Mavor, Mayor, Miller, Murad, Muratani, Nakayama, Nantel, Nicholls, Odds, Ozkaynak, Paiva, Peng, Radivojac, Rechsteiner, Rodaki, Roig, Roig, Roig, Santt, Saville, Sepulveda, Seyfried, Sherman, Shi, Skrzypek, Smith, Stadtman, Staub, Stead, Stevenson, Sudbery, Swoboda, Tagwerker, Tanaka, Thewes, Vizcaino, Walther, Weissman, Werner-Washburne, Wilson, Wimalasena, Wolf, Yin, Zakikhany   +94 more
core   +2 more sources