The ‘Amoeboid Predator-Fungal Animal Virulence’ Hypothesis [PDF]
Journal of Fungi, 2019 The observation that some aspects of amoeba-fungal interactions resemble animal phagocytic cell-fungal interactions, together with the finding that amoeba passage can enhance the virulence of some pathogenic fungi, has stimulated interest in the amoeba ...
Arturo Casadevall +3 more
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Breaking the bad: Bacillus blocks fungal virulence factors [PDF]
Microbial Cell, 2017 Fungal pathogens rely on the production of specific virulence factors during infection. Inhibiting such factors generally results in reduced fungal pathogenicity.
François L. Mayer, James W. Kronstad
doaj +4 more sources
Secreted fungal virulence effector triggers allergic inflammation via TLR4. [PDF]
Nature, 2022 Invasive fungal pathogens are major causes of human mortality and morbidity1,2. Although numerous secreted effector proteins that reprogram innate immunity to promote virulence have been identified in pathogenic bacteria, so far, there are no examples of analogous secreted effector proteins produced by human fungal pathogens.
Dang EV +5 more
europepmc +6 more sources
Journal of Applied Sciences and Environmental Management, 2004 This paper presents a comprehensive literature review of cell wall degrading enzymes (CWDEs). Plant pathogenic fungi secrete extracellular enzymes that are capable of degrading the cell walls of their host plants.
N. J Tonukari
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IP7-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery
mBio, 2020 In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate signaling pathway is critical for virulence. We recently demonstrated the key role of the inositol pyrophosphate IP7 (isomer 5-PP-IP5) in driving fungal virulence; however,
Desmarini Desmarini +11 more
doaj +2 more sources
Procatechuic acid and protocatechuic aldehyde increase survival of Caenorhabditis elegans after fungal infection and inhibit fungal virulence [PDF]
Front PharmacolProtocatechuic acid (PCA) and protocatechuic aldehyde (PAL) are important phenolic compounds in plants. We here investigated their possible beneficial effect against fungal infection and the underlying mechanism.
Yuan C, Wang Y, Zhang L, Wang D.
europepmc +2 more sources
Metals in fungal virulence [PDF]
FEMS Microbiology Reviews, 2017 Metals are essential for life, and they play a central role in the struggle between infecting microbes and their hosts. In fact, an important aspect of microbial pathogenesis is the ‘nutritional immunity’, in which metals are actively restricted (or, in ...
Franziska Gerwien +4 more
semanticscholar +3 more sources
Proteome signatures reveal homeostatic and adaptive oxidative responses by a putative co-chaperone, Wos2, to influence fungal virulence determinants in cryptococcosis [PDF]
Microbiology SpectrumThe increasing prevalence of invasive fungal pathogens is dramatically changing the clinical landscape of infectious diseases, posing an imminent threat to public health.
Brianna Ball +7 more
doaj +2 more sources
A Predicted Mannoprotein Cmp1 Regulates Fungal Virulence in Cryptococcus neoformans. [PDF]
Pathogens, 2020 The capsule of the fungal pathogen Cryptococcus neoformans consists of glucuronoxylomannan (GXM), glucuronoxylomannogalactan (GXMGal), and mannoproteins (MPs).
Han LT, Wu L, Liu TB.
europepmc +2 more sources
Xylose donor transport is critical for fungal virulence
PLOS Pathogens, 2018 Cryptococcus neoformans, an AIDS-defining opportunistic pathogen, is the leading cause of fungal meningitis worldwide and is responsible for hundreds of thousands of deaths annually.
Lucy X Li +3 more
semanticscholar +6 more sources