Results 21 to 30 of about 645,266 (318)

Synergistic Action of a Metalloprotease and a Serine Protease from Fusarium oxysporum f. sp. lycopersici Cleaves Chitin-Binding Tomato Chitinases, Reduces Their Antifungal Activity, and Enhances Fungal Virulence

Molecular Plant-Microbe Interactions, 2015
As part of their defense strategy against fungal pathogens, plants secrete chitinases that degrade chitin, the major structural component of fungal cell walls.
Mansoor Karimi Jashni, Ivo H. M. Dols, Yuichiro Iida, Sjef Boeren, Henriek G. Beenen, Rahim Mehrabi, Jérôme Collemare, Pierre J. G. M. de Wit   +7 more
doaj   +2 more sources

Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress [PDF]

, 2012
Acknowledgments We thank Alexander Johnson (yhb1D/D), Karl Kuchler (sodD/D mutants), Janet Quinn (hog1D/D, hog1/cap1D/D, trx1D/D) and Peter Staib (ssu1D/D) for providing mutant strains.
A Cederlund, A da Silva Dantas, Alistair J. P. Brown, B Amulic, B Enjalbert, B Enjalbert, B Hube, B Hube, BD Ullmann, Bernhard Hube, BH Youseff, BS Hromatka, C Fradin, Christine Dunker, CJ Barelle, CJ Barelle, CJ Heilmann, D Wilson, DA Smith, DL Moyes, DL Moyes, DM Arana, DR Wysong, FC Fang, GM Chaves, Hanna Windecker, I Rubin-Bejerano, I Wozniok, ID Jacobsen, IE Frohner, Iryna M. Bohovych, J Cheetham, M de Jesus-Berrios, M Martchenko, MA Wheeler, MC Lorenz, MC Lorenz, MG Netea, Oliver Kurzai, Oscar Zaragoza, P Nordenfelt, Pedro Miramón, R Alonso-Monge, R Pathania, RA Calderone, RI Lehrer, SC Cheng, TM Stevanin, TM Stevanin, V Brinkmann, W Bellamy, W Chiranand   +51 more
core   +32 more sources

Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery [PDF]

Journal of Fungi, 2016
Opportunistic fungi are a major cause of morbidity and mortality world-wide, particularly in immunocompromised individuals. Developing new treatments to combat invasive fungal disease is challenging given that fungal and mammalian host cells are ...
Cecilia Li, Sophie Lev, A. Saiardi, Desmarini Desmarini, T. Sorrell, J. Djordjevic   +5 more
semanticscholar   +5 more sources

Calcineurin Targets Involved in Stress Survival and Fungal Virulence

PLOS Pathogens, 2016
Calcineurin governs stress survival, sexual differentiation, and virulence of the human fungal pathogen Cryptococcus neoformans. Calcineurin is activated by increased Ca2+ levels caused by stress, and transduces signals by dephosphorylating protein ...
Hee-Soo Park, E. W. L. Chow, Ci Fu, E. Soderblom, M. Moseley, J. Heitman, M. Cárdenas, A. Mitchell   +7 more
semanticscholar   +5 more sources

Conflicting interests in the pathogen-host tug of war : fungal micronutrient scavenging versus mammalian nutritional immunity [PDF]

, 2014
Funding: The authors are supported by the European Research Council (STRIFE project funded on grant number ERC-2009-AdG-249793, http://erc.europa.eu). AJPB is also supported by the Wellcome Trust (grant numbers 080088, 097377, www.wellcome.ac.uk) and the
Ballou, Elizabeth R, Brown, Alistair J P, Childers, Delma S, Potrykus, Joanna   +3 more
core   +14 more sources

How metals fuel fungal virulence, yet promote anti-fungal immunity.

Dis Model Mech, 2023
ABSTRACT Invasive fungal infections represent a significant global health problem, and present several clinical challenges, including limited treatment options, increasing rates of antifungal drug resistance and compounding comorbidities in affected patients.
Alselami A, Drummond RA.
europepmc   +4 more sources

Fungal morphogenesis and virulence [PDF]

Medical Mycology, 2000
Phenotypic variability in pathogenic fungi has long been correlated with virulence, but specific genetic and molecular mechanisms are only recently being unraveled. Fungal morphogenesis, reflecting the expression of several regulated genes, and the capacity of the rising forms or phases to cause disease has been focused on at the XIVth Congress of the ...
G, San-Blas, L R, Travassos, B C, Fries, D L, Goldman, A, Casadevall, A K, Carmona, T F, Barros, R, Puccia, M K, Hostetter, S G, Shanks, V M, Copping, Y, Knox, N A, Gow   +12 more
openaire   +2 more sources

Linking fungal morphogenesis with virulence [PDF]

Cellular Microbiology, 2002
Pathogenic fungi have become an increasingly common cause of systemic disease in healthy people and those with impaired immune systems. Although a vast number of fungal species inhabit our planet, just a small number are pathogens, and one feature that links many of them is the ability to differentiate morphologically from mould to yeast, or yeast to ...
Peggy J, Rooney, Bruce S, Klein
openaire   +2 more sources

ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence. [PDF]

PLoS Pathogens, 2014
The Aspergillus fumigatus sterol regulatory element binding protein (SREBP) SrbA belongs to the basic Helix-Loop-Helix (bHLH) family of transcription factors and is crucial for antifungal drug resistance and virulence.
Dawoon Chung, Bridget M Barker, Charles C Carey, Brittney Merriman, Ernst R Werner, Beatrix E Lechner, Sourabh Dhingra, Chao Cheng, Wenjie Xu, Sara J Blosser, Kengo Morohashi, Aurélien Mazurie, Thomas K Mitchell, Hubertus Haas, Aaron P Mitchell, Robert A Cramer   +15 more
doaj   +1 more source

Peptidases: promising antifungal targets of the human fungal pathogen, Cryptococcus neoformans

FACETS, 2022
Cryptococcus neoformans is a globally important fungal pathogen, primarily inflicting disease on immunocompromised individuals. The widespread use of antifungal agents in medicine and agriculture supports the development of antifungal resistance through ...
Davier Gutierrez-Gongora, Jennifer Geddes-McAlister   +1 more
doaj   +1 more source