Results 41 to 50 of about 65,240 (304)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The dose rate debate: does the risk of fungicide resistance increase or decrease with dose? [PDF]

, 2011
This paper reviews the evidence relating to the question: does the risk of fungicide resistance increase or decrease with dose? The development of fungicide resistance progresses through three key phases.
R. Oliver, Oliver, Richard, Shaw, Michael, F. van den Bosch, M. Shaw, Hobbelen, P., van den Bosch, F., Oliver, R., Paveley, N., Shaw, M., Hobbelin, P., P. Hobbelen, N. Paveley   +12 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The Mechanisms of Developing Fungicide Resistance in Fusarium graminearum Causing Fusarium Head Blight and Fungicide Resistance Management

Pathogens
Fusarium head blight (FHB), primarily caused by Fusarium graminearum, is one of the economically significant diseases in small grains. FHB causes severe damage to wheat production and grain quality.
Malini Anudya Jayawardana, Wannakuwattewaduge Gerard Dilantha Fernando   +1 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Experimental control strategies reducing the fungicide input at a practical scale [PDF]

, 2010
Phytophthora infestans is the most devastating disease in potato cultivation. Chemical control is necessary to ensure a healthy crop. At the same time Dutch governmental policy asks for a reduction of the environmental impact of potato late blight ...
van Bekkum, P.J., Kessel, G.J.T., Evenhuis, A., Schepers, H.T.A.M., Spruijt, J., Bekkum, P.J., van   +5 more
core  

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Mechanisms of action of the organophosphorus fungicide pyrazophos [PDF]

, 1974
In plant protection organophosphorus compounds are well-known for their insecticidal and acaricidal action. Since 1960, a number of organophosphorus fungicides have also been introduced.
de Waard, M.A., Waard, M.A., de
core  

Molecular characterization of cellulose synthase (CesA) genes and impact of mutations on fungicide resistance in oomycetes [PDF]

, 2012
Many oomycetes are important pathogens of plants (e.g. arable crops, fruit and forest trees), animals or microbes and, upon attacking their hosts, cause considerable economic damage mainly in agriculture and aquaculture.
Blum, Mathias
core   +1 more source

Environmental behavior assessment Thiophanate methyl in the soil using different mathematical models

Kufa Journal for Agricultural Sciences
One of the most common fungicides, Thiophanate-methyl (TM), has been extensively used to prevent fusarium wilt disease. Understanding the kinetic behavior of the TM-fungicide in the greenhouse soil was aimed at the current research.
Hawraa Mehdi Saleh, Alaa Hassan A Al-Farttoosy   +1 more
doaj   +1 more source