Results 231 to 240 of about 54,327 (289)

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Exploration of the Phytochemical and Antidiabetic Properties of Teucrium polium: A Natural Asset for Type 2 Diabetes Management

ChemistryOpen, EarlyView.
Teucrium polium shows antidiabetic activity with its phytochemical composition and biological activities. The essential oil is rich in carvacrol, thymol, γ‐terpinene, and o‐cymene, while the aqueous and hydroethanolic extracts are characterized by poliumoside, verbascoside, isorhamnetin‐3‐O‐rutinoside, and apigenin‐7‐rutinoside. Antioxidant activity is
Hajar El Ouadni, Aziz Drioiche, Fadoua El Makhoukhi, Omkulthom Al kamaly, Hannou Zerkani, Smail Amalich, Imane Tagnaout, Mohamed Radi, Yahya Cherrah, Touriya Zair, Katim Alaoui   +10 more
wiley   +1 more source

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Hyperkeratotic Tinea Pedis

JEADV Clinical Practice, EarlyView.
Sunil Jaiswal, Shraddha Uprety, Pratichya Thapa, Aditi Joshi, Prakriti Lamichhane   +4 more
wiley   +1 more source

Social and cultural considerations for the restoration of ‘lost’ tree species: The fall and rise of elm

People and Nature, EarlyView.
Abstract Attempts to address biodiversity loss have led to ecosystem and species restoration efforts. Tree species restoration is particularly relevant because of increasing threats from pests and pathogens. However, there are different notions of ‘loss’, as well as sociocultural considerations, including social acceptability, which are often neglected
Fritha West, Rehema M. White, Althea L. Davies, Richard Buggs, Mariella Marzano   +4 more
wiley   +1 more source

Combining social, ecological and economic approaches in knowledge co‐production enables the identification of sustainable farming options

People and Nature, EarlyView.
Abstract Farming systems face an increasing sustainability challenge requiring integrated solutions to minimize the trade‐offs between the social, ecological and economic dimensions of sustainability. Yet, most research remains siloed, limiting interdisciplinary understanding of farming systems as coupled social‐ecological systems (SESs) and precluding
Neema R. Kinabo, Dominic A. Martin, Koggani D. Koggani, Berta Martín‐López, Milena Gross, Christian Schleyer, Verena Hackmann, Andreas Thiel, Katrin Böhning‐Gaese, Peter Manning   +9 more
wiley   +1 more source

Fungicide resistance-related investigations

Matzen, Niels, Beck, Brittany Deanna, Frederiksen, Birgitte Boyer, Jørgensen, Lise Nistrup   +3 more
openaire   +1 more source

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Genetics of Fungicide Resistance

2015
Acquired resistance to fungicides in fungal plant pathogens is a challenge in modern crop protection. Fungi are indeed very able to adapt to changing environmental conditions, such as the introduction of a new fungicide in the agricultural practice. Several genetic mechanisms may underlay fungicide resistance and influence the chance and time of its ...
DE MICCOLIS ANGELINI, RITA MILVIA, POLLASTRO, Stefania, FARETRA, Francesco   +2 more
openaire   +2 more sources

Understanding resistance to Anilinopyrimidine fungicides

2023
Anilinopyrimidines (AP) are a chemical class of fungicides that are effective against a broad range of phytopathogenic fungi. Cyprodinil, mepanipyrim and pyrimethanil belonging to this class are currently available in the market. Resistance to AP fungicides has been reported in various fungal species from many crops worldwide, and control failure has ...
Seiya Saito, Chang-Lin Xiao
openaire   +1 more source

Fungicide Resistance—Lessons for Herbicide Resistance Management?

Weed Technology, 1995
Resistance to agricultural fungicides has increaséd dramatically in the past twenty years, following the introduction of systemic fungicides. Disease control failures associated with fungicide resistance have occurred with many classes of fungicides and in many genera of plant-pathogenic fungi. In some cases, resistance evolved extremely rapidly making
Tobin L. Peever, Michael G. Milgroom
openaire   +1 more source