Results 61 to 70 of about 2,045,645 (315)

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Invention and Industrialization of New Optically Active Triazolyl Plant Growth Regulator and Fungicide.

NIPPON KAGAKU KAISHI, 1994
著者らが先に見出した殺菌剤ブチオオートの構造活性相関や作用機作研究の結果を活用した分子設計により,強い植物生畏調節活性と殺菌活性を餅せ持つ新規な2-(トリアゾリル)アリルアルコール系化合物を得た.本化合物には幾何異性体と光学異性体が存在する。E異性体の活性はZ異性体に比して大幅に向上すること,また,檀物生長鯛節活性はS体に,殺菌活性はR体に集中していることを明らかにし,二つの薬効の分離に成功した,前者はジべレリンの,後者はエルゴステロールの生合成を選択的に阻害する。製造法では,E/Z異性化技術と分離技術を組み合わせた異性化晶析法を開発し,E体を選択的に合成する簡便な工業的製造法を確立した。また,新規な不斉修飾剤であるアミノアルコールと水素化アルミニウムリチウムを用いる ...
Shizuya TANAKA, Yuji FUNAKI, Gohfu SUZUKAMO, Yukio YONEYOSHI, Kazuhiro TADA   +4 more
openaire   +2 more sources

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

Effect of adjuvants on the efficiency of benthiavalicarb plus mancozeb (Valbon 1.6 kg/ha) on the control of late blight in potato [PDF]

, 2009
Industrial adjuvants were tested in combination with benthiavalicarb plus mancozeb (Valbon 1.6 kg/ha) in the field to investigate their efficacy on foliar late blight caused by Phytophthora infestans.
De Schampheleire, Mieke, Dewitte, Kevin, Haesaert, Geert, Heremans, Betty, Pycke, Bart, Spanoghe, Pieter, Steurbaut, Walter   +6 more
core   +1 more source

Soil and water pollution in a banana production region in tropical Mexico [PDF]

, 2010
The effects of abundant Mancozeb (Mn, Zn— bisdithiocarbamate) applications (2.5 kg ha-1week-1 for 10 years) on soil and surface-, subsurface- and groundwater pollution were monitored in a banana production region of tropical Mexico.
Bastidas-Bastidas, P.J., de, Bello-Mendoza, R., Díaz-González, G., Geissen, V., Huerta-Lwanga, E., Que Ramos, F., Ruiz-Suárez, L.E.   +6 more
core   +3 more sources

Off-purpose activity of industrial and agricultural chemicals against human gut bacteria

bioRxiv
Contamination by industrial and agricultural chemicals like pesticides are a cause of great concern due to the risk to human and environmental health. While these chemicals are often considered to have restricted activity and are labelled as such, there ...
Anna E. Lindell, Stephan Kamrad, Indra Roux, Shagun Krishna, A. Grießhammer, Tom S. Smith, Rui Guan, Deniz Rad, Luisa Faria, Sonja Blasche, Nicole C. Kleinstreuer, Lisa Maier, K. R. Patil   +12 more
semanticscholar   +1 more source

Few‐Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell‐Like Phenotypes

Advanced Healthcare Materials, EarlyView.
Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar, Peifu Cheng, Tugce Dogruel, Maxsam Donta, Juhyung Jung, Naomi A. Asante, Donald S. Sakaguchi, Surya K. Mallapragada, Piran R. Kidambi, Metin Uz   +9 more
wiley   +1 more source

THE PROSPECTS OF EASTERN SIBERIA Trichoderma FUNGI FOR PHYTOPATHO-GEN CONTROL

Siberian Journal of Life Sciences and Agriculture
Background. Throughout the world, the losses of agricultural products are associated with plant diseases, most often caused by microscopic fungi. Among the most effective methods to control these fungi is the use of various chemicals fungicides. However,
Victoria E. Kuznetsova, Elena A. Matveeva, Lyudmila A. Belovezhets   +2 more
doaj   +1 more source

Fungicide application technology for controlling the sugarcane orange rust [PDF]

, 2019
With the epidemic onset of the sugarcane orange rust, fungicide applications of the Strobilurins and Triazoles groups have become necessary in susceptible varieties.
Alves, Guilherme Sousa, Alves, Thales Cassemiro, Rodrigues da Cunha, João Arantes, Silva, Sérgio Macedo, Tavares, Rafael Marcão   +4 more
core   +1 more source

Fungicide Registration and a Small Niche Market: A Case History of Hymexazol Seed Treatment and the U.S. Sugar Beet Industry [PDF]

Plant Disease, 2007
The United States ranks among the top four sugar producers worldwide, and sugar beet (Beta vulgaris L.) plays a major role in the sweetener industry. Sugar beet was planted on approximately 553,100 ha (1.37 million acres) in 2006 (33). The greatest volume of production occurs in the Red River Valley (RRV) of Minnesota and North Dakota and in southern ...
Harveson, R. M., Windels, C. E., Smith, J. A., Brantner, J. R., Cattanach, A. W., Giles, J. F., Hubbell, L., Cattanach, N. R.   +7 more
openaire   +2 more sources