Results 41 to 50 of about 2,211 (233)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Clinical evaluation of platelet rich fibrin as barrier membrane in treatment of grade II furcation defects

Journal of Indian Society of Periodontology
Background and Objectives: Various guided tissue regenerative procedures have been used in treatment of furcation defects. A combination of various graft materials and barrier membranes have been used over a period of time. The present study was designed
B. Harshavardhana, Nitin Gupta, Spandana Reddy Vantary, Ankit Krishna   +3 more
doaj   +1 more source

Quantifying Subsurface Weak in‐Plane Magnetization of Mixed Phase BiFeO3 by Scanning Nitrogen Vacancy Magnetometry

Advanced Functional Materials, EarlyView.
We use scanning nitrogen vacancy magnetometry to directly image the weak in‐plane magnetic moments in mixed phase BiFeO3 at the nanoscale and quantify the local magnetic moments to be 18.8±2.0 μB/nm2 in the rhombohedral‐like phase and 1.5±0.6 μB/nm2 in the well‐known non‐magnetic tetragonal‐like phase.
Lei Wang, Zhewen Xu, Yuwen Xu, Björn Josteinsson, Simon Josephy, Dawei Zhang, Yunlong Sun, Heung‐Sik Park, Jihun Kim, Kanghyun Chu, Kyung Song, Danyang Wang, Chan‐Ho Yang, Andrea Morales, Jan Seidel   +14 more
wiley   +1 more source

A novel approach in the management of mandibular degree II furcation defects using bone grafts in conjunction with a biomimetic agent: A randomized controlled clinical trial

Journal of Indian Society of Periodontology, 2020
Aim: Of the periodontal defects requiring regeneration, degree II furcation defects pose a substantial challenge to clinicians. This study was designed to evaluate the relative effectiveness of bone autograft (BA) and autologous platelet-rich fibrin (PRF)
Koyyalamudi Prudhvi, Katragadda Raja Venkatesh Murthy   +1 more
doaj   +1 more source

Evaluation of Gengigel® Application in the Management of Furcation with Coronally Advanced Flap through Surgical Re-Entry-A Split Mouth Clinical Study [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: One of the challenging and unique periodontal problem of Grade II furcation defect has been managed through different treatment modalities in the past. A successful approach is based on complete closure of the defect.
Sugandha Gupta, Suresh D Kediege, Akanksha Gupta, Kanu Jain   +3 more
doaj   +1 more source

Clinical success of guided tissue regeneration for treating vertical bone and furcation defects in dogs

Frontiers in Veterinary Science, 2023
This study evaluated the clinical success rate of guided tissue regeneration (GTR) for treating advanced periodontal disease in a large canine cohort. A total of 112 GTR procedures performed from 2003–2021 were retrospectively evaluated, including pre ...
Bonnie L. Lee, Jason Soukup, Aaron Rendahl, Stephanie Goldschmidt   +3 more
doaj   +1 more source

Saving A Mandibular Molar With Furcation Involvement And Root Resorption

International Dental Journal
Introduction: External root resorption (ERR) and class III furcation defect are both factors that can lead to tooth extraction. In this case study, the affected tooth with external root resorption and furcation involvement (FI) class III was successfully
Wang Wenjuan
doaj   +1 more source

The Use of Cone-Beam Computed Tomography in Furcation Defects Diagnosis

Balkan Journal of Dental Medicine, 2016
Background: The use of cone-beam computed tomography (CBCT), as an additional diagnostic tool in daily dental practice, has expanded rapidly in recent years.
Cimbaljevic M., Misic J., Jankovic, S., Nikolic-Jakoba N.   +3 more
doaj   +1 more source