Results 151 to 160 of about 1,603,600 (233)

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, EarlyView.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

Prior Tooth Mobility and Furcation Involvement Are Associated With Higher Dental Implant Failure Rates: A Propensity‐Matched Cohort Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives To compare the long‐term survival of dental implants placed in sites with a documented pre‐operative history of severe tooth mobility or advanced furcation involvement against a matched control group. Material and Methods This retrospective cohort study analyzed patient records from a multi‐university network.
Georgios S. Chatzopoulos, Larry F. Wolff
wiley   +1 more source

Use of Platelet-Rich Fibrin in the Treatment of Grade 2 Furcation Defects: Systematic Review and Meta-Analysis. [PDF]

J Clin Med, 2020
Tarallo F, Mancini L, Pitzurra L, Bizzarro S, Tepedino M, Marchetti E.   +5 more
europepmc   +1 more source

Single‐Cell Virtual Perturbation Screening Identifies STAT3 as a Key Regulator of Dentinogenesis

Cell Proliferation, EarlyView.
STAT3 promotes odontoblast differentiation in dental mesenchymal cells by transcriptionally regulating WNT2B via the canonical Wnt/β‐catenin signalling pathway. These findings elucidate a mechanism underlying dentine development. ABSTRACT Dentine formation constitutes a physiological process precisely regulated by signal transduction modules governing ...
Yanfei Zhu, Hongyuan Xu, Zijian Zhang, Siyuan Sun, Zihan Huang, Xin Gao, Houwen Pan, Xiangru Huang, Yuanqi Liu, Xinyu Wang, Hanbin Jia, Qinggang Dai, Lingyong Jiang   +12 more
wiley   +1 more source

Alteration in oral and non‐oral tissues in ligature‐induced periodontitis mice with the Alzheimer's disease risk factor APOE4

European Journal of Oral Sciences, EarlyView.
Abstract The APOE4 gene, particularly the ε4 allele, is linked to susceptibility to Alzheimer's disease, and periodontitis can cause pathological changes in multiple organs, but combined effects of these conditions and the impact of tumor necrosis factor (TNF)‐α regulation on the combined effects remain unclear.
Ae Ri Kim, Yun‐Jung Yoo, Eun‐Jung Bak   +2 more
wiley   +1 more source

Homologous recombination mutants cause differing lethality between h− and h+ Schizosaccharomyces pombe strains due to mat1 heterochromatin

The FEBS Journal, EarlyView.
Homologous recombination (HR) in Schizosaccharomyces pombe is essential when mating‐type switching–induced double‐strand breaks (DSBs) form at the mat1 locus. In h90 and h− strains, efficient mat1 DSB formation renders HR indispensable unless suppressors block these breaks.
Peter Kolesar, Siarhei Paliavoi, Barbora Stefanovie, Jan Josef Palecek   +3 more
wiley   +1 more source

The Firebrands Echo: National Fantasy as an Obstacle to Jean‐Luc Mélenchon's Populist Spectacle

Constellations, EarlyView.
Reid A. Kleinberg
wiley   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Enchanting the Otherwise: Magical Realism and the Gendered Ontologies of Organizational Becoming

Gender, Work &Organization, EarlyView.
ABSTRACT This paper enacts a feminist‐posthumanist reimagining of gender as ontological disturbance, using magical realism not as metaphor but as epistemological method. Rejecting representational logics and the managerial rationalities of organizational realism, we advance gender not as identity or role but as spectral interference—a transversal ...
Max Ganzin, Diana Ivanycheva
wiley   +1 more source

Comparison Between the 2017 EFP/AAP and CDC/AAP Case Definitions on Periodontal Status and Their Association With Risk Factors in an Adult Norwegian Population—Insights From the Tromsø Study: Tromsø7

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objectives To describe the prevalence, extent and severity of periodontitis in an adult Norwegian population, using the 2017 EFP/AAP and CDC/AAP case definitions, and their associations with potential risk factors for periodontitis. A secondary aim was to explore how the stage and grade of periodontitis shifted when complexity and risk factors
Gro Eirin Holde, Dagmar Fosså Bunæs, Birgitta Jönsson   +2 more
wiley   +1 more source