Results 181 to 190 of about 28,655 (201)
Some of the next articles are maybe not open access.
Current Medicinal Chemistry, 2010
Processing of cancer-associated precursor proteins such as growth factors by the Proprotein Convertase furin is an important cellular process for acquisition of malignant phenotype and metastatic potential of tumor cells. Furin is inhibited by its own prodomain protein which also plays role in the folding of mature furin.
A, Basak +5 more
openaire +2 more sources
Processing of cancer-associated precursor proteins such as growth factors by the Proprotein Convertase furin is an important cellular process for acquisition of malignant phenotype and metastatic potential of tumor cells. Furin is inhibited by its own prodomain protein which also plays role in the folding of mature furin.
A, Basak +5 more
openaire +2 more sources
Optimization of Substrate‐Analogue Furin Inhibitors
ChemMedChem, 2017AbstractThe proprotein convertase furin is a potential target for drug design, especially for the inhibition of furin‐dependent virus replication. All effective synthetic furin inhibitors identified thus far are multibasic compounds; the highest potency was found for our previously developed inhibitor 4‐(guanidinomethyl)phenylacetyl‐Arg‐Tle‐Arg‐4 ...
Teodora Ivanova +10 more
openaire +2 more sources
Precursor Processing by Kex2/Furin Proteases
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Nathan C, Rockwell +3 more
openaire +2 more sources
Internally Quenched Fluorogenic Substrate for Furin
Analytical Biochemistry, 1995A new substrate for furin, Abz-Arg-Val-Lys-Arg-Gly-Leu-Ala-Tyr(NO2)-Asp-OH, has been synthesized and characterized. The peptide is an internally quenched fluorogenic substrate. The kinetic parameters are Km = 3.8 microM, kcat = 29.3 s-1, and kcat/KM = 7,710,000 M-1 s-1.
H, Angliker +3 more
openaire +2 more sources
Journal of Medicinal Chemistry, 2021
Analysis of the SARS-CoV-2 sequence revealed a multibasic furin cleavage site at the S1/S2 boundary of the spike protein distinguishing this virus from SARS-CoV. Furin, the best-characterized member of the mammalian proprotein convertases, is an ubiquitously expressed single pass type 1 transmembrane protein.
Essam Eldin A. Osman +2 more
openaire +2 more sources
Analysis of the SARS-CoV-2 sequence revealed a multibasic furin cleavage site at the S1/S2 boundary of the spike protein distinguishing this virus from SARS-CoV. Furin, the best-characterized member of the mammalian proprotein convertases, is an ubiquitously expressed single pass type 1 transmembrane protein.
Essam Eldin A. Osman +2 more
openaire +2 more sources
Colloquium Series on Protein Activation and Cancer, 2012
Abstract The proprotein convertase Furin is a serine endoprotease which cleaves protein precursors carboxyterminal of basic residues in motifs such as Arg–X–X–Arg and Lys/Arg–Arg. Cleavage usually results in activation of the proprotein but can also inactivate or modify the activity.
Jeroen Declercq, J.W.M. Creemers
openaire +1 more source
Abstract The proprotein convertase Furin is a serine endoprotease which cleaves protein precursors carboxyterminal of basic residues in motifs such as Arg–X–X–Arg and Lys/Arg–Arg. Cleavage usually results in activation of the proprotein but can also inactivate or modify the activity.
Jeroen Declercq, J.W.M. Creemers
openaire +1 more source
1994
Abstract Furin is the translation product encoded by the fur locus, which was initially identified by its proximity to the fes/fps proto-oncogene (fes/fps JJ.pstream region)3. Furin cDNAs have been isolated from several species including human, mouse, rat and Xenopus4-8.
openaire +1 more source
Abstract Furin is the translation product encoded by the fur locus, which was initially identified by its proximity to the fes/fps proto-oncogene (fes/fps JJ.pstream region)3. Furin cDNAs have been isolated from several species including human, mouse, rat and Xenopus4-8.
openaire +1 more source
[Furin and its biological role].
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2008The survey deals with structure, properties and biological role of furin, the calcium-dependent serine endoprotease, which is expressed in all tissues and cell lines examined. It is the best-characterized representative of the mammalian subtilisin-like family of proprotein convertases, which is capable to cleave precursors of a wide variety of proteins,
V K, Kibirev +2 more
openaire +1 more source
[New non-peptide inhibitors of furin].
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 2010Furin, a human subtilisin-related proprotein convertase, is the most important pharmaceutical target because it plays a vital role in development of numerous disease processes. To identify a new class of small non-peptide inhibitors of furin we performed a study of several flavonoids and some natural products.
V K, Kibirev +3 more
openaire +1 more source