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Photoaddition by Furocoumarins
1994In photobiology, the photoreactions involving the formation of C4-cyclobutane type adducts in DNA, such as the formation of pyrimidine dimers (Setlow and Carrier, 1966) by short wave UV radiation and the photoaddition of furocoumarins to pyrimidines in DNA (Musajo and Rodighiero, 1972; Hearst et al., 1984), have been of particular importance because of
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Furocoumarin photolysis: chemical and biological aspects
Photochemical & Photobiological Sciences, 2002Furocoumarins (psoralens) undergo photolysis when subjected to UVA radiation in solution. Several products are formed, depending on the molecular structure and experimental conditions. Some products are the result of anoxic mechanisms (cyclodimerisation, addition of solvent), others of oxic pathways, leading to oxidised products. The mechanisms thought
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Furocoumarins ofCnidium dubium
Chemistry of Natural Compounds, 19661. Paper chromatography has shown that the fruit ofC. dubium contains not less than eight substances of coumarinic nature; six of these (A, B, C, D, E, and H) have been isolated in the crystalline state. 2. Substances B, D, and E are identical with isoimperatorin, imperatorin, and oxypeucedanin, respectively.
N. F. Komissarenko, V. T. Chernobai
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The skin-photosensitizing furocoumarins
Experientia, 1962L, MUSAJO, G, RODIGHIERO
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Photochemical Reactions of Furocoumarins
1982The recent line of research in the field of furocoumarins, de veloped for obtaining new agents able to photosensitize biological substrates only through monofunctional photolesions to DNA, is discussed. The interactions between a group of methylderivatives of angelicin, recently prepared, and DNA both in the ground and in the excited state are referred.
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Photochemotherapy with Furocoumarins (Psoralens)
1982Photochemotherapy is the combined use of a photosensitizing chemical compound with non-ionizing electromagnetic radiation to bring about a therapeutically beneficial result not produced by the drug or radiation alone. The drug may be applied topically or administered systemically to reach the skin via the circulation and is subsequently activated by ...
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Mechanisms of photosensitization by furocoumarins.
National Cancer Institute monograph, 1985Furocoumarins photosensitize biomolecules to 320- to 400-nm UV by way of Type I (sensitizer-substrate) and Type II (sensitizer-oxygen) mechanisms. The Type I reactions with DNA are mediated by ground state complexes. Covalent monoadducts of the furocoumarin with pyrimidines are formed in the first photochemical step.
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Diethylaminoalkyloxycoumarin and -furocoumarin derivatives.
Il Farmaco; edizione scientifica, 1981Four series of diethylaminoalkoxyderivatives of coumarin (at the positions 4 and 7) and furocoumarin (at the positions 5 and 8) have been prepared, in order to study their complexing capacity with DNA, these compounds having a double possibility of interaction, that is intercalation of the aromatic moiety between two base pairs and formation of an ...
C, Antonello +5 more
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Photoreactive states of furocoumarins.
National Cancer Institute monograph, 1985On the basis of spectroscopic and wave-function analyses of the excited states of psoralens, it is predicted that the photocycloaddition at the 3,4-double bond leading to the formation of a monoadduct proceeds from both the singlet and triplet excited states, with the latter state being the preferential route, especially in the reactions between ...
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