Results 251 to 260 of about 70,600 (345)

The bookend effect. [PDF]

open access: yesIperception
Riga A   +3 more
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

open access: yesAdvanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer   +9 more
wiley   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

open access: yesAdvanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen   +5 more
wiley   +1 more source

Climate stressor projections inform adaptation needs in South Asian oilseed systems. [PDF]

open access: yesNPJ Sustain Agric
Barik A   +6 more
europepmc   +1 more source

Peroxisomal DBP deficiency causes male infertility through disruption of lipid homeostasis in Drosophila. [PDF]

open access: yesCell Mol Life Sci
Wang J   +7 more
europepmc   +1 more source

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