Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
Four new species of the genus <i>Lyroda Say</i> (Hymenoptera, Crabronidae) from China, with a key to Chinese species. [PDF]
Li C, Li Q, Ma L.
europepmc +1 more source
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen +5 more
wiley +1 more source
Dermoscopic Features of Plantar and Palmar Melanocytic Nevi in Children: Dermoscopy of Children's Plantar and Palmar Melanocytic Nevi. [PDF]
Cui Z, Wu J, Fang L, Ren C.
europepmc +1 more source
Three new species and four new records of the genus <i>Aleuroclava</i> Singh (Hemiptera, Aleyrodidae) from China, with the first description of seasonal dimorphism in the genus. [PDF]
Lin QS, Wang JR.
europepmc +1 more source
Climate stressor projections inform adaptation needs in South Asian oilseed systems. [PDF]
Barik A +6 more
europepmc +1 more source
Bitesize bundles F-actin and influences actin remodeling in syncytial Drosophila embryo development. [PDF]
Yeh AR +4 more
europepmc +1 more source
Peroxisomal DBP deficiency causes male infertility through disruption of lipid homeostasis in Drosophila. [PDF]
Wang J +7 more
europepmc +1 more source

