Results 41 to 50 of about 15,094 (245)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Multi-responsive shape memory polymer printed by fused deposition modeling technique
eXPRESS Polymer Letters, 2020 With the help of three-dimensional (3D) printing technique, complicated and sophisticated structured shape memory polymers (SMPs) devices could be obtained, which have drawn tremendous attention in recent years. However, there is technical limitation for
J. Liu +4 more
doaj +1 more source
Fused deposition modelling using direct extrusion
Virtual and Physical Prototyping, 2007 In the present work, a process based on the principle of polymer extrusion is developed: the extruder deposition process (EDP). This system uses a screw extruder to deposit the material on a computer-controlled positioning system to build components.
B. V. Reddy, N. V. Reddy, A. Ghosh
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
High-resolution fused deposition 3D printing based on electric-field-driven jet
工程科学学报, 2019 The existing fused deposition modeling (FDM) technique faces disadvantages of low resolution and limited printable materials; meanwhile the E-jet-based fused deposition method confronts limitations associated with the formation height, material type ...
ZHAO Jia-wei +4 more
doaj +1 more source
eXPRESS Polymer Letters, 2021 The effect of crack propagation management by using a fused deposition modeling (FDM) technique on the environmental stress cracking (ESC) behavior of neat polycarbonate (PC) and PC with 1 vol% SiO2 nanocomposites were investigated.
M. Z. Huang, J. Nomai, A. K. Schlarb
doaj +1 more source
Fused Deposition Modelling of Polymer Composite: A Progress
Polymers, 2022 Additive manufacturing (AM) highlights developing complex and efficient parts for various uses. Fused deposition modelling (FDM) is the most frequent fabrication procedure used to make polymer products. Although it is widely used, due to its low characteristics, such as weak mechanical properties and poor surface, the types of polymer material that may
J Mogan +7 more
openaire +3 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source