Results 41 to 50 of about 16,101 (261)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Biodegradable Poly(Lactic Acid) Nanocomposites for Fused Deposition Modeling 3D Printing
Nanomaterials, 2020 3D printing by fused deposition modelling (FDM) enables rapid prototyping and fabrication of parts with complex geometries. Unfortunately, most materials suitable for FDM 3D printing are non-degradable, petroleum-based polymers.
Madison Bardot, Michael D. Schulz
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
High-resolution fused deposition 3D printing based on electric-field-driven jet
工程科学学报, 2019 The existing fused deposition modeling (FDM) technique faces disadvantages of low resolution and limited printable materials; meanwhile the E-jet-based fused deposition method confronts limitations associated with the formation height, material type ...
ZHAO Jia-wei +4 more
doaj +1 more source
Effect of using 3D-printed shell structure for reinforcement of ultra-high-performance concrete
Structural Mechanics of Engineering Constructions and Buildings, 2023 This study aims to investigate the effect of 3D-printed polymer shell reinforcemen ton ultra-high-performance concrete. The mechanical properties of ultra-high-performance polymer reinforced concrete have been investigated. At first, the 3D-printed shell
Mohammad Hematibahar +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Multi-responsive shape memory polymer printed by fused deposition modeling technique
eXPRESS Polymer Letters, 2020 With the help of three-dimensional (3D) printing technique, complicated and sophisticated structured shape memory polymers (SMPs) devices could be obtained, which have drawn tremendous attention in recent years. However, there is technical limitation for
J. Liu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
eXPRESS Polymer Letters, 2021 The effect of crack propagation management by using a fused deposition modeling (FDM) technique on the environmental stress cracking (ESC) behavior of neat polycarbonate (PC) and PC with 1 vol% SiO2 nanocomposites were investigated.
M. Z. Huang, J. Nomai, A. K. Schlarb
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A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline
FEBS Open Bio, EarlyView.Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey +4 more
wiley +1 more source