Results 51 to 60 of about 2,393,079 (270)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Energy Consumption Prediction for Fused Deposition Modelling 3D Printing Using Machine Learning

Applied System Innovation, 2022
Additive manufacturing (AM) technologies are growing more and more in the manufacturing industry; the increase in world energy consumption encourages the quantification and optimization of energy use in additive manufacturing processes.
Mohamed Achraf El youbi El idrissi, Loubna Laaouina, Adil Jeghal, Hamid Tairi, Moncef Zaki   +4 more
doaj   +1 more source

Curved-layer fused deposition modelling

Journal for New Generation Sciences, 2010
Curved-layer fused deposition ...
Diegel, Olaf, Singamneni, Sarat, Gibson, Ian   +2 more
core   +3 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Effect of support on printed properties in fused deposition modelling processes

Virtual and Physical Prototyping, 2019
Additive manufacturing still suffers from redundant support material usage when printing parts with overhanging features. All the supports will be removed after fabrication, resulting in wasted materials.
Jingchao Jiang, Jingjun Lou, Guobiao Hu
doaj   +1 more source

Mechanical properties and failure analysis of PLA/copper composites fabricated by fused deposition modelling [PDF]

Journal of Mining and Metallurgy. Section B: Metallurgy
The Fused Deposition Modelling process is an additive manufacturing process that is influenced by numerous parameters that affect the strength of the components.
Kumar R.V., Kumar K.R., Soms N.
doaj   +1 more source

National Atmospheric Deposition Program 2011 Annual summary [PDF]

, 2012
is peer reviewedSubmitted by Susan Braxton (braxton@illinois.edu) on 2013-01-29T22:55:31Z No. of bitstreams: 1 2011as.pdf: 4443124 bytes, checksum: 1e2ff568a6e350fe41bba46c81de3531 (MD5)Made available in DSpace on 2013-01-29T22:55:31Z (GMT). No.
National Atmospheric Deposition Program
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source