Results 81 to 90 of about 252,665 (316)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Effects of CNC Machining on Surface Roughness in Fused Deposition Modelling (FDM) Products. [PDF]

Materials (Basel), 2020
Fused deposition modelling (FDM) opens new ways across the industries and helps to produce complex products, yielding a prototype or finished product.
Lalegani Dezaki M, Mohd Ariffin MKA, Ismail MIS.   +2 more
europepmc   +2 more sources

Mechanical properties and failure analysis of PLA/copper composites fabricated by fused deposition modelling [PDF]

Journal of Mining and Metallurgy. Section B: Metallurgy
The Fused Deposition Modelling process is an additive manufacturing process that is influenced by numerous parameters that affect the strength of the components.
Kumar R.V., Kumar K.R., Soms N.
doaj   +1 more source

3D printing a transposed design in biopolymer materials using an articulated robot and pellet-based extrusion : a thesis presented in partial fulfilment of the requirements for a degree of Master of Engineering in Mechatronics at Massey University, Albany, New Zealand [PDF]

, 2016
The aim of this project was to develop a new method of 3D printing. This method is a mix between Fused Deposition Modelling and freeform printing, using a 6 degree-of-freedom articulated robot and a pellet-based extruder to mix and distribute the ...
Brooks, Byron
core  

Fabrication and optimisation of a fused filament 3D-printed microfluidic platform [PDF]

, 2017
A 3D-printed microfluidic device was designed and manufactured using a low cost ($2000) consumer grade fusion deposition modelling (FDM) 3D printer.
James, Stephen W., Partridge, Matthew, Tatam, Ralph P., Tothill, Alexander M.   +3 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Rapid Prototyping: Technologies, Materials and Advances

Archives of Metallurgy and Materials, 2016
In the context of product development, the term rapid prototyping (RP) is widely used to describe technologies which create physical prototypes directly from digital data.
Dudek P., Rapacz-Kmita A.
doaj   +1 more source