Results 111 to 120 of about 1,277,311 (250)

De puentes y precipicios: la ampliación del Mercosur como propuesta alternativa estratégica de Uruguay [PDF]

open access: yes, 2013
El proceso de integración en América Latina se halla en pleno período de transición. Mientras el Mercosur se encuentra embarcado en una crisis multidimensional, sus miembros se han sumado a un nuevo proyecto de alcance suramericano, representado en la ...
Braslovsky, Nicolás   +1 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Valoración a Banco Bogotá, BBVA, Occidente, y Popular para determinar si el valor generado por la fusión con las compañías de leasing fue superior al valor cuando eran entidades independientes [PDF]

open access: yes, 2017
Después de aprobarse la Ley 1328 del 15 de julio de 2009 a los establecimientos bancarios, se les da la potestad de realizar operaciones de leasing, facultad otorgada únicamente por las Compañías de Financiamiento Comercial o Compañías de Financiamiento,
López Sosa, Jorge Enrique   +1 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Sostenibilidad energética a largo plazo. El papel de la fusión nuclear [PDF]

open access: yes, 2011
En este artículo se realiza una disertación sobre la sostenibilidad energética y la contribución de las diferentes energías a ella, analizando con especial énfasis el papel que desempeña la fusión nuclear en el desarrollo ...
Jiménez Varas, Gonzalo   +1 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Does post merger financial performance improve after agrifood mergers of cooperatives? An empirican analysis [PDF]

open access: yes
This study was carried out to characterize the mergers and acquisitions undertaken in the Spanish agrifood sector during the period 1995-2005 and has two objectives.
Julia-Igual, Juan F.   +2 more
core   +1 more source

Caracterización y purificación de una proteína de fusión [PDF]

open access: yes, 2014
Traballo fin de grao (UDC.CIE). Bioloxía.
Calvo López, Tania
core  

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

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