Results 21 to 30 of about 1,069,690 (246)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

La alúmina como material aislante en la fusión termonuclear : efecto de la incorporación de carbono en las propiedades físicas [PDF]

, 2008
Entre los aislantes cerámicos candidatos para ser utilizados en los reactores de fusión termonuclear, la alúmina se presenta como el más idóneo dada sus excelentes propiedades dieléctricas y su gran resistencia a la radiación.
Román Chacón, Raquel
core  

Reduced electrostatic turbulence in the quasi-isodynamic stellarator configuration CIEMAT-QI4

Nuclear Fusion
CIEMAT-QI4 is a quasi-isodynamic stellarator configuration that simultaneously features very good fast-ion confinement in a broad range of β values, low neoclassical transport and bootstrap current, and ideal magnetohydrodynamic stability up to $\beta ...
J.M. García-Regaña, I. Calvo, E. Sánchez, H. Thienpondt, J.L. Velasco, J.A. Capitán   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Fusión de dos empresas nacionales [PDF]

, 2023
El presente trabajo trata sobre la fusión de dos empresas y sus respectivas plantas, donde la finalidad es entender la situación actual y aspectos relevantes de la situación futura, identificar posibles impactos y opciones para mitigar los mismos en la ...

core  

CIEMAT-QI4X: a reactor-relevant quasi-isodynamic stellarator configuration compatible with an island divertor

Nuclear Fusion
A four-field-period quasi-isodynamic stellarator configuration is presented that exhibits small neoclassical and electrostatic turbulent transport, good fast-ion confinement over a wide range of β values, small bootstrap current and an edge island ...
E. Sánchez, J.L. Velasco, I. Calvo, J.M. García-Regaña, C. Salcuni, J.A. Alonso   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Non uniform thickness neutron spectrum shifter to fit radiation BB effects on material in IFMIF-DONES

Nuclear Engineering and Technology
The International Fusion Materials Irradiation Facility – Demo Oriented Neutron Source (IFMIF-DONES) plays an essential role in testing and qualifying materials for the development of nuclear fusion technology.
F. Mota, M.I. Ortiz, F. Arranz, B. Brañas, D. Rapisarda   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source