Results 81 to 90 of about 1,069,690 (246)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Fusión conceptual y analogía

, 2005
Se enuncia la teoría de la fusión conceptual que avanza sobre la teoría bipolar de la proyección. En la teoría de la fusión existen cuatro dominios que son objeto de diversas operaciones, algunas proyectivas y otras de mezcla y unión de dominios diversos,
Fauconnier, Gilles
core  

Caso Práctico: Fusión por Absorción

, 2020
Titulación::Postgrado::Máster Universitario en Derecho de la EmpresaAl contar A.U S.L con el 100% de las participaciones de R.I S.L, nos encontramos ante una fusión por absorción impropia, regulada con un régimen especial por el artículo 49 LME.
Montes García, Belén
core  

Erratum: ‘A quasi-isodynamic configuration with good confinement of fast ions at low plasma β’(2023 Nucl. Fusion 63 066037)

Nuclear Fusion, 2023
E. Sánchez, J.L. Velasco, I. Calvo, S. Mulas   +3 more
doaj   +1 more source

Early stages of self-healing at tungsten grain boundaries from ab initio machine learning simulations

Communications Materials
Nanostructured tungsten has been reported as a possible alternative plasma–facing material due to its potential ability to self–heal radiation-induced defects, a property that is attributed to its high density of grain boundaries (GB). Here, we study the
Jorge Suárez-Recio, Pablo M. Piaggi, Francisco J. Domínguez-Gutiérrez, Raquel Gonzalez-Arrabal, Roberto Iglesias   +4 more
doaj   +1 more source

Superposición restringida de imágenes

Industrial Data, 2012
Se presenta un algoritmo para seleccionar un conjunto de píxeles por encima de un cierto nivel de gris en una imagen, extraerlo y transferirlo a otra imagen; el resultado es una superposición restringida de imágenes, basada en la técnica de diferencia ...
Javier Montenegro Joo
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source