Results 111 to 120 of about 1,777,078 (318)

Axial confinement in the Novatron mirror machine

Nuclear Fusion
The Novatron magnetic mirror fusion reactor concept features significant advantages. These include stability against MHD interchange and kinetic drift cyclotron loss cone modes, axisymmetry, and minimized radial particle drifts and neoclassical losses ...
J. Scheffel, J. Jäderberg, K. Bendtz, R. Holmberg, K. Lindvall   +4 more
doaj   +1 more source

Development of a Telemetric, Miniaturized Electrochemical Amperometric Analyzer

Sensors, 2017
In this research, we developed a portable, three-electrode electrochemical amperometric analyzer that can transmit data to a PC or a tablet via Bluetooth communication.
Jaehyo Jung, Jihoon Lee, Siho Shin, Youn Tae Kim   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Differential cargo mobilisation within Weibel-Palade bodies after transient fusion with the plasma membrane. [PDF]

, 2014
Inflammatory chemokines can be selectively released from Weibel-Palade bodies (WPBs) during kiss-and-run exocytosis. Such selectivity may arise from molecular size filtering by the fusion pore, however differential intra-WPB cargo re-mobilisation ...
Knipe, Laura, Tom Carter (196826), Carter, T, Laura Knipe (196817), Hannah, MJ, Kiskin, Nikolai I, Kiskin, NI, Nikolai I Kiskin, Matthew J. Hannah (196824), Matthew J Hannah, Babich, Victor, Nikolai I. Kiskin (631240), Victor Babich, Knipe, L, Tom Carter, Victor Babich (631241), Laura Knipe, Carter, Tom, Babich, V, Hannah, Matthew J   +19 more
core   +1 more source

Real-time data-driven disruption prediction and its mitigation of MA-plasma experiments in KSTAR with a lower carbon divertor

Nuclear Fusion
Real-time disruption prediction and its mitigation of mega-ampere (MA) plasma experiments have been performed in the 2022 KSTAR carbon lower divertor condition.
Jeongwon Lee, Sang-hee Hahn, Hyunsun Han, Jayhyun Kim, June-Woo Juhn, Jun-Gyo Bak, Jae-in Song, YongUn Nam   +7 more
doaj   +1 more source

Logic of fusion

CoRR, 2020
The starting point of this work is the observation that the Curry-Howard isomorphism, relating types and propositions, programs and proofs, composition and cut, extends to the correspondence of program fusion and cut elimination. This simple idea suggests logical interpretations of some of the basic methods of generic and transformational programming ...
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Exploration of a Fast Pathway to Nuclear Fusion: Thermal Analysis and Cooling Design Considerations for the ARC Reactor

, 2020
Progress in technological fields such as high-temperature superconductors, additive manufacturing, and innovative materials has led to new scenarios and to a second generation of fusion reactor designs.
Zucchetti, Massimo, Whyte, Dennis G, Hartwig, Zachary Seth   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source