Results 111 to 120 of about 1,982,523 (302)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Realising fusion systems

open access: yes, 2007
We show that every fusion system (saturated or not) on a p-group S is equal to the fusion system associated to a discrete group G containing S as a subgroup and such that every finite subgroup of G is conjugate to a subgroup of ...
Stancu, Radu, Leary, Ian J.
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Fusion product studies via fast ion D–D and D–3He fusion on JET

open access: yes, 2016
Dedicated fast ion D-D and D-3He fusion experiments were performed on JET with carbon wall (2008) and ITER-like wall (2014) for testing the upgraded neutron and energetic ion diagnostics of fusion products.
Mantsinen, M   +58 more
core   +1 more source

Complete remission of NUP98 fusion-positive acute myeloid leukemia with the covalent menin inhibitor BMF-219, icovamenib

open access: yesHaematologica
Not available.
Hetty E. Carraway   +10 more
doaj   +1 more source

Radar HRRP Target Recognition Based on Deep One-Dimensional Residual-Inception Network

open access: yesIEEE Access, 2019
A novel radar target recognition method based on the deep one-dimensional residual-inception network is proposed for a high-resolution range profile (HRRP).
Chen Guo   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Report by the Joint-Core Team for the Establishment of Technology Bases Required for the Development of a Fusion DEMO Reactor - Basic Concept of DEMO and Structure of Technological Issues- [PDF]

open access: yes, 2015
In accordance with the request of the Working Group on Fusion Research, the Nuclear Science and Technology Committee, the Subdivision on R&D Planning and Evaluation, the Council for Science and Technology, the Ministry of Education, Culture, Sports ...
OKANO, Kunihiko   +11 more
core  

Cell fusion [PDF]

open access: yesWormBook, 2006
Selective cell fusion is a natural part of development. It is found in sexually reproducing organisms that require fertilization to propagate and in muscles, placenta, bones, lens of the eye and stem cells. Cell fusion is particularly important in the development of C. elegans: in addition to 300 sperm and oocytes that fuse during fertilization, 300 of
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

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